Pathophysiology of ‘positive’ thought disorder in schizophrenia
Formal thought disorder is a characteristic feature of psychosis, but little is known of its pathophysiology. We have investigated this in schizophrenia using positron emission tomography (PET). Regional cerebral blood flow was measured using H2(15)O and PET while six people with schizophrenia were...
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| Veröffentlicht in: | British journal of psychiatry 1998-09, Vol.173 (3), p.231-235 |
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| creator | McGuire, Philip Quested, Digby Spence, Sean Murray, Robin Frith, Christopher Liddle, Peter |
| description | Formal thought disorder is a characteristic feature of psychosis, but little is known of its pathophysiology. We have investigated this in schizophrenia using positron emission tomography (PET).
Regional cerebral blood flow was measured using H2(15)O and PET while six people with schizophrenia were describing a series of 12 ambiguous pictures which elicited different degrees of thought-disordered speech. In a within-subject design, the severity of 'positive' thought disorder was correlated with cerebral blood flow across the 12 scans in each subject.
Verbal disorganisation (positive thought disorder) was inversely correlated with activity in the inferior frontal, cingulate and left superior temporal cortex, and positively correlated with activity in the parahippocampal/anterior fusiform region bilaterally, and in the body of the right caudate (P < 0.001). The total amount of speech produced (independent of thought disorder) was positively correlated with activity in the left inferior frontal and left superior temporal cortex.
The severity of positive thought disorder was inversely correlated with activity in areas implicated in the regulation and monitoring of speech production. Reduced activity in these regions may contribute to the articulation of the linguistic anomalies that characterise positive thought disorder. The positive correlations between positive thought disorder and parahippocampal/anterior fusiform activity may reflect this region's role in the processing of linguistic anomalies. |
| doi_str_mv | 10.1192/bjp.173.3.231 |
| format | Article |
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Regional cerebral blood flow was measured using H2(15)O and PET while six people with schizophrenia were describing a series of 12 ambiguous pictures which elicited different degrees of thought-disordered speech. In a within-subject design, the severity of 'positive' thought disorder was correlated with cerebral blood flow across the 12 scans in each subject.
Verbal disorganisation (positive thought disorder) was inversely correlated with activity in the inferior frontal, cingulate and left superior temporal cortex, and positively correlated with activity in the parahippocampal/anterior fusiform region bilaterally, and in the body of the right caudate (P < 0.001). The total amount of speech produced (independent of thought disorder) was positively correlated with activity in the left inferior frontal and left superior temporal cortex.
The severity of positive thought disorder was inversely correlated with activity in areas implicated in the regulation and monitoring of speech production. Reduced activity in these regions may contribute to the articulation of the linguistic anomalies that characterise positive thought disorder. The positive correlations between positive thought disorder and parahippocampal/anterior fusiform activity may reflect this region's role in the processing of linguistic anomalies.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.173.3.231</identifier><identifier>PMID: 9926099</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Ambiguity ; Articulation ; Blood flow ; Cerebral blood flow ; Cerebrovascular Circulation ; Cognition Disorders - pathology ; Cognition Disorders - physiopathology ; Cognition Disorders - psychology ; Cortex ; Humans ; Male ; Mental disorders ; Middle Aged ; Neuroimaging ; Parahippocampal gyrus ; Pathophysiology ; Positron emission tomography ; Positron emission tomography (PET) ; Psychosis ; Schizophrenia ; Schizophrenia - pathology ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Speech ; Speech Disorders - pathology ; Speech Disorders - physiopathology ; Speech production ; Temporal lobe ; Thinking ; Thought disorder ; Tomography ; Tomography, Emission-Computed</subject><ispartof>British journal of psychiatry, 1998-09, Vol.173 (3), p.231-235</ispartof><rights>Copyright © 1998 The Royal College of Psychiatrists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-f3cbae61461b0f13cd0ba6c76e3ec9c702c6ee15da7193e8cc7a321dfaad70863</citedby><cites>FETCH-LOGICAL-c448t-f3cbae61461b0f13cd0ba6c76e3ec9c702c6ee15da7193e8cc7a321dfaad70863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S000712500026114X/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,12845,27923,27924,30998,55627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9926099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McGuire, Philip</creatorcontrib><creatorcontrib>Quested, Digby</creatorcontrib><creatorcontrib>Spence, Sean</creatorcontrib><creatorcontrib>Murray, Robin</creatorcontrib><creatorcontrib>Frith, Christopher</creatorcontrib><creatorcontrib>Liddle, Peter</creatorcontrib><title>Pathophysiology of ‘positive’ thought disorder in schizophrenia</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>Formal thought disorder is a characteristic feature of psychosis, but little is known of its pathophysiology. We have investigated this in schizophrenia using positron emission tomography (PET).
Regional cerebral blood flow was measured using H2(15)O and PET while six people with schizophrenia were describing a series of 12 ambiguous pictures which elicited different degrees of thought-disordered speech. In a within-subject design, the severity of 'positive' thought disorder was correlated with cerebral blood flow across the 12 scans in each subject.
Verbal disorganisation (positive thought disorder) was inversely correlated with activity in the inferior frontal, cingulate and left superior temporal cortex, and positively correlated with activity in the parahippocampal/anterior fusiform region bilaterally, and in the body of the right caudate (P < 0.001). The total amount of speech produced (independent of thought disorder) was positively correlated with activity in the left inferior frontal and left superior temporal cortex.
The severity of positive thought disorder was inversely correlated with activity in areas implicated in the regulation and monitoring of speech production. Reduced activity in these regions may contribute to the articulation of the linguistic anomalies that characterise positive thought disorder. The positive correlations between positive thought disorder and parahippocampal/anterior fusiform activity may reflect this region's role in the processing of linguistic anomalies.</description><subject>Adult</subject><subject>Ambiguity</subject><subject>Articulation</subject><subject>Blood flow</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Circulation</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognition Disorders - psychology</subject><subject>Cortex</subject><subject>Humans</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Parahippocampal gyrus</subject><subject>Pathophysiology</subject><subject>Positron emission tomography</subject><subject>Positron emission tomography (PET)</subject><subject>Psychosis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Speech</subject><subject>Speech Disorders - pathology</subject><subject>Speech Disorders - physiopathology</subject><subject>Speech production</subject><subject>Temporal lobe</subject><subject>Thinking</subject><subject>Thought disorder</subject><subject>Tomography</subject><subject>Tomography, Emission-Computed</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkEtLw0AUhQdRan0sXQoRwV3aeSSZzlKKLyjoQtfDZHLTTGk7cSZR4qo_Q_9ef4kjLYri6nI53z33cBA6IXhAiKDDfFYPCGcDNqCM7KA-STiNSZKlu6iPMeYxoSneRwfez8LKEsp7qCcEzbAQfTR-UE1l66rzxs7ttItsGa1X77X1pjEvsF59REFvp1UTFcZbV4CLzDLyujJv4czB0qgjtFequYfj7TxET9dXj-PbeHJ_cze-nMQ6SUZNXDKdK8hCNJLjkjBd4FxlmmfAQAvNMdUZAEkLxYlgMNKaK0ZJUSpVcDzK2CG62PjWzj634Bu5MF7DfK6WYFsvM0HSVHARwPM_4My2bhmyScoETjFNRzxQ8YbSznrvoJS1MwvlOkmw_KpWhmplqFaycEYCf7p1bfMFFN_0tsugn230ykyrV-NAOl37Tle_PIbbn2qRO1NM4Sfa_18_ASm3kfE</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>McGuire, Philip</creator><creator>Quested, Digby</creator><creator>Spence, Sean</creator><creator>Murray, Robin</creator><creator>Frith, Christopher</creator><creator>Liddle, Peter</creator><general>Cambridge University Press</general><general>RCP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7T9</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>Pathophysiology of ‘positive’ thought disorder in schizophrenia</title><author>McGuire, Philip ; Quested, Digby ; Spence, Sean ; Murray, Robin ; Frith, Christopher ; Liddle, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-f3cbae61461b0f13cd0ba6c76e3ec9c702c6ee15da7193e8cc7a321dfaad70863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Ambiguity</topic><topic>Articulation</topic><topic>Blood flow</topic><topic>Cerebral blood flow</topic><topic>Cerebrovascular Circulation</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognition Disorders - psychology</topic><topic>Cortex</topic><topic>Humans</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Parahippocampal gyrus</topic><topic>Pathophysiology</topic><topic>Positron emission tomography</topic><topic>Positron emission tomography (PET)</topic><topic>Psychosis</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Speech</topic><topic>Speech Disorders - pathology</topic><topic>Speech Disorders - physiopathology</topic><topic>Speech production</topic><topic>Temporal lobe</topic><topic>Thinking</topic><topic>Thought disorder</topic><topic>Tomography</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McGuire, Philip</creatorcontrib><creatorcontrib>Quested, Digby</creatorcontrib><creatorcontrib>Spence, Sean</creatorcontrib><creatorcontrib>Murray, Robin</creatorcontrib><creatorcontrib>Frith, Christopher</creatorcontrib><creatorcontrib>Liddle, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Linguistics and Language Behavior Abstracts (LLBA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McGuire, Philip</au><au>Quested, Digby</au><au>Spence, Sean</au><au>Murray, Robin</au><au>Frith, Christopher</au><au>Liddle, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathophysiology of ‘positive’ thought disorder in schizophrenia</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>173</volume><issue>3</issue><spage>231</spage><epage>235</epage><pages>231-235</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>Formal thought disorder is a characteristic feature of psychosis, but little is known of its pathophysiology. We have investigated this in schizophrenia using positron emission tomography (PET).
Regional cerebral blood flow was measured using H2(15)O and PET while six people with schizophrenia were describing a series of 12 ambiguous pictures which elicited different degrees of thought-disordered speech. In a within-subject design, the severity of 'positive' thought disorder was correlated with cerebral blood flow across the 12 scans in each subject.
Verbal disorganisation (positive thought disorder) was inversely correlated with activity in the inferior frontal, cingulate and left superior temporal cortex, and positively correlated with activity in the parahippocampal/anterior fusiform region bilaterally, and in the body of the right caudate (P < 0.001). The total amount of speech produced (independent of thought disorder) was positively correlated with activity in the left inferior frontal and left superior temporal cortex.
The severity of positive thought disorder was inversely correlated with activity in areas implicated in the regulation and monitoring of speech production. Reduced activity in these regions may contribute to the articulation of the linguistic anomalies that characterise positive thought disorder. The positive correlations between positive thought disorder and parahippocampal/anterior fusiform activity may reflect this region's role in the processing of linguistic anomalies.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>9926099</pmid><doi>10.1192/bjp.173.3.231</doi><tpages>5</tpages></addata></record> |
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| ispartof | British journal of psychiatry, 1998-09, Vol.173 (3), p.231-235 |
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| source | MEDLINE; Cambridge Journals; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Ambiguity Articulation Blood flow Cerebral blood flow Cerebrovascular Circulation Cognition Disorders - pathology Cognition Disorders - physiopathology Cognition Disorders - psychology Cortex Humans Male Mental disorders Middle Aged Neuroimaging Parahippocampal gyrus Pathophysiology Positron emission tomography Positron emission tomography (PET) Psychosis Schizophrenia Schizophrenia - pathology Schizophrenia - physiopathology Schizophrenic Psychology Speech Speech Disorders - pathology Speech Disorders - physiopathology Speech production Temporal lobe Thinking Thought disorder Tomography Tomography, Emission-Computed |
| title | Pathophysiology of ‘positive’ thought disorder in schizophrenia |
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