Effect Of Structural Relaxation On The Preparation And Drug Release Behavior Of Poly(lactic-co-glycolic)acid Microparticle Drug Delivery Systems

Control of burst release is a major challenge in the development of poly(lactide-co-glycolide) (PLGA) microparticle drug delivery systems. It has been well-documented in previous literature that formulation and processing variables determine particle morphology, which in turn, governs drug diffusivi...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2008-06, Vol.97 (6), p.2022-2035
1. Verfasser:	Allison, S. Dean
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences calorimetry (DSC) Chemistry, Pharmaceutical controlled release/delivery Diffusion Drug Carriers Drug Compounding General pharmacology glass Glycolates - chemistry Kinetics Lactic Acid Medical sciences microencapsulation microparticles Models, Chemical Molecular Structure Particle Size Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments physical stability PLA poly(lactic/glycolic)acid (PLGA Polyglycolic Acid Solubility Technology, Pharmaceutical - methods thermodynamics
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