Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions
Metabolic syndrome (MetS) is a recognized risk factor for stroke, but it is unclear whether MetS is also related to subclinical ischemic lesions. We examined the association of MetS with the prevalence of silent brain infarction, periventricular hyperintensity, and subcortical white matter lesions i...
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| Veröffentlicht in: | Stroke (1970) 2008-05, Vol.39 (5), p.1607-1609 |
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| container_title | Stroke (1970) |
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| creator | BOKURA, Hirokazu YAMAGUCHI, Shuhei IIJIMA, Kenichi NAGAI, Atsushi OGURO, Hiroaki |
| description | Metabolic syndrome (MetS) is a recognized risk factor for stroke, but it is unclear whether MetS is also related to subclinical ischemic lesions. We examined the association of MetS with the prevalence of silent brain infarction, periventricular hyperintensity, and subcortical white matter lesions in healthy adults.
We conducted a cross-sectional study in 1151 Japanese healthy subjects. Three types of silent lesions were assessed by MRI scans. MetS was diagnosed using the criteria by the National Cholesterol Education Adult Treatment Panel III.
After adjusting for age and other factors, MetS was significantly associated with silent brain infarction, periventricular hyperintensity and subcortical white matter lesions. Among the MetS components, elevated blood pressure was commonly associated with all types of lesions. Dyslipidemia and elevated fasting glucose levels were associated with subcortical white matter lesions and periventricular hyperintensities, respectively. Positive trends were observed between the number of MetS components and prevalence of silent lesions.
MetS is associated with the prevalence of silent lesions independent of other risk factors. The clustering of MetS components tends to increase the prevalence of silent lesions. |
| doi_str_mv | 10.1161/STROKEAHA.107.508630 |
| format | Article |
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We conducted a cross-sectional study in 1151 Japanese healthy subjects. Three types of silent lesions were assessed by MRI scans. MetS was diagnosed using the criteria by the National Cholesterol Education Adult Treatment Panel III.
After adjusting for age and other factors, MetS was significantly associated with silent brain infarction, periventricular hyperintensity and subcortical white matter lesions. Among the MetS components, elevated blood pressure was commonly associated with all types of lesions. Dyslipidemia and elevated fasting glucose levels were associated with subcortical white matter lesions and periventricular hyperintensities, respectively. Positive trends were observed between the number of MetS components and prevalence of silent lesions.
MetS is associated with the prevalence of silent lesions independent of other risk factors. The clustering of MetS components tends to increase the prevalence of silent lesions.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.107.508630</identifier><identifier>PMID: 18323475</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Brain - pathology ; Brain - physiopathology ; Brain Infarction - epidemiology ; Brain Infarction - pathology ; Brain Infarction - physiopathology ; Brain Ischemia - epidemiology ; Brain Ischemia - pathology ; Brain Ischemia - physiopathology ; Causality ; Comorbidity ; Cross-Sectional Studies ; Dyslipidemias - epidemiology ; Dyslipidemias - physiopathology ; Female ; Humans ; Hyperglycemia - epidemiology ; Hyperglycemia - physiopathology ; Hypertension - epidemiology ; Hypertension - physiopathology ; Japan - epidemiology ; Leukoaraiosis - epidemiology ; Leukoaraiosis - pathology ; Leukoaraiosis - physiopathology ; Male ; Medical sciences ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - physiopathology ; Middle Aged ; Nerve Fibers, Myelinated - pathology ; Neurology ; Pharmacology. Drug treatments ; Prevalence ; Risk Factors ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2008-05, Vol.39 (5), p.1607-1609</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-3f13bc835cd3e1365be7aaba3d5b1894a9f0e9ae758075cfaab69be653d12aff3</citedby><cites>FETCH-LOGICAL-c448t-3f13bc835cd3e1365be7aaba3d5b1894a9f0e9ae758075cfaab69be653d12aff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20320881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18323475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOKURA, Hirokazu</creatorcontrib><creatorcontrib>YAMAGUCHI, Shuhei</creatorcontrib><creatorcontrib>IIJIMA, Kenichi</creatorcontrib><creatorcontrib>NAGAI, Atsushi</creatorcontrib><creatorcontrib>OGURO, Hiroaki</creatorcontrib><title>Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Metabolic syndrome (MetS) is a recognized risk factor for stroke, but it is unclear whether MetS is also related to subclinical ischemic lesions. We examined the association of MetS with the prevalence of silent brain infarction, periventricular hyperintensity, and subcortical white matter lesions in healthy adults.
We conducted a cross-sectional study in 1151 Japanese healthy subjects. Three types of silent lesions were assessed by MRI scans. MetS was diagnosed using the criteria by the National Cholesterol Education Adult Treatment Panel III.
After adjusting for age and other factors, MetS was significantly associated with silent brain infarction, periventricular hyperintensity and subcortical white matter lesions. Among the MetS components, elevated blood pressure was commonly associated with all types of lesions. Dyslipidemia and elevated fasting glucose levels were associated with subcortical white matter lesions and periventricular hyperintensities, respectively. Positive trends were observed between the number of MetS components and prevalence of silent lesions.
MetS is associated with the prevalence of silent lesions independent of other risk factors. The clustering of MetS components tends to increase the prevalence of silent lesions.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Infarction - epidemiology</subject><subject>Brain Infarction - pathology</subject><subject>Brain Infarction - physiopathology</subject><subject>Brain Ischemia - epidemiology</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Causality</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Dyslipidemias - epidemiology</subject><subject>Dyslipidemias - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperglycemia - epidemiology</subject><subject>Hyperglycemia - physiopathology</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - physiopathology</subject><subject>Japan - epidemiology</subject><subject>Leukoaraiosis - epidemiology</subject><subject>Leukoaraiosis - pathology</subject><subject>Leukoaraiosis - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Middle Aged</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Neurology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAURS0EoqXwDxDKAluK7Wcn9liqQiuKKtEixshxXlSjfJQ4HfrvCWpURqYnvXvuHQ4ht4yOGYvY43rzvnqdTeaTMaPxWFIVAT0jQya5CEXE1TkZUgo65ELrAbny_otSykHJSzJgCjiIWA7J9A1bk9aFs8H6UGVNXWKw8MHE-9o602IWfLp2G6xdgVXbJXaLZcc-NcZVwRK9qyt_TS5yU3i86e-IfDzPNtN5uFy9LKaTZWiFUG0IOYPUKpA2A2QQyRRjY1IDmUyZ0sLonKI2GEtFY2nzLot0ipGEjHGT5zAiD8fdXVN_79G3Sem8xaIwFdZ7n0SaSQGS_wtyGmkuIO5AcQRtU3vfYJ7sGlea5pAwmvxaTk6Wu0-cHC13tbt-f5-WmP2Veq0dcN8DxltT5I2prPMnjlPgVCkGP7-fhbg</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>BOKURA, Hirokazu</creator><creator>YAMAGUCHI, Shuhei</creator><creator>IIJIMA, Kenichi</creator><creator>NAGAI, Atsushi</creator><creator>OGURO, Hiroaki</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions</title><author>BOKURA, Hirokazu ; YAMAGUCHI, Shuhei ; IIJIMA, Kenichi ; NAGAI, Atsushi ; OGURO, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-3f13bc835cd3e1365be7aaba3d5b1894a9f0e9ae758075cfaab69be653d12aff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Infarction - epidemiology</topic><topic>Brain Infarction - pathology</topic><topic>Brain Infarction - physiopathology</topic><topic>Brain Ischemia - epidemiology</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Causality</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Dyslipidemias - epidemiology</topic><topic>Dyslipidemias - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperglycemia - epidemiology</topic><topic>Hyperglycemia - physiopathology</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - physiopathology</topic><topic>Japan - epidemiology</topic><topic>Leukoaraiosis - epidemiology</topic><topic>Leukoaraiosis - pathology</topic><topic>Leukoaraiosis - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Middle Aged</topic><topic>Nerve Fibers, Myelinated - pathology</topic><topic>Neurology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOKURA, Hirokazu</creatorcontrib><creatorcontrib>YAMAGUCHI, Shuhei</creatorcontrib><creatorcontrib>IIJIMA, Kenichi</creatorcontrib><creatorcontrib>NAGAI, Atsushi</creatorcontrib><creatorcontrib>OGURO, Hiroaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOKURA, Hirokazu</au><au>YAMAGUCHI, Shuhei</au><au>IIJIMA, Kenichi</au><au>NAGAI, Atsushi</au><au>OGURO, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>39</volume><issue>5</issue><spage>1607</spage><epage>1609</epage><pages>1607-1609</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Metabolic syndrome (MetS) is a recognized risk factor for stroke, but it is unclear whether MetS is also related to subclinical ischemic lesions. We examined the association of MetS with the prevalence of silent brain infarction, periventricular hyperintensity, and subcortical white matter lesions in healthy adults.
We conducted a cross-sectional study in 1151 Japanese healthy subjects. Three types of silent lesions were assessed by MRI scans. MetS was diagnosed using the criteria by the National Cholesterol Education Adult Treatment Panel III.
After adjusting for age and other factors, MetS was significantly associated with silent brain infarction, periventricular hyperintensity and subcortical white matter lesions. Among the MetS components, elevated blood pressure was commonly associated with all types of lesions. Dyslipidemia and elevated fasting glucose levels were associated with subcortical white matter lesions and periventricular hyperintensities, respectively. Positive trends were observed between the number of MetS components and prevalence of silent lesions.
MetS is associated with the prevalence of silent lesions independent of other risk factors. The clustering of MetS components tends to increase the prevalence of silent lesions.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>18323475</pmid><doi>10.1161/STROKEAHA.107.508630</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain - pathology Brain - physiopathology Brain Infarction - epidemiology Brain Infarction - pathology Brain Infarction - physiopathology Brain Ischemia - epidemiology Brain Ischemia - pathology Brain Ischemia - physiopathology Causality Comorbidity Cross-Sectional Studies Dyslipidemias - epidemiology Dyslipidemias - physiopathology Female Humans Hyperglycemia - epidemiology Hyperglycemia - physiopathology Hypertension - epidemiology Hypertension - physiopathology Japan - epidemiology Leukoaraiosis - epidemiology Leukoaraiosis - pathology Leukoaraiosis - physiopathology Male Medical sciences Metabolic Syndrome - epidemiology Metabolic Syndrome - physiopathology Middle Aged Nerve Fibers, Myelinated - pathology Neurology Pharmacology. Drug treatments Prevalence Risk Factors Vascular diseases and vascular malformations of the nervous system |
| title | Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions |
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