SERS--a single-molecule and nanoscale tool for bioanalytics

Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibration...

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Veröffentlicht in:Chemical Society reviews 2008-05, Vol.37 (5), p.1052-1060
Hauptverfasser: Kneipp, Janina, Kneipp, Harald, Kneipp, Katrin
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creator Kneipp, Janina
Kneipp, Harald
Kneipp, Katrin
description Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibrational spectroscopy in biology. The concept of SERS can be extended to two-photon excitation by exploiting surface enhanced hyper-Raman scattering (SEHRS). This critical review introduces the physics behind single-molecule SERS and discusses the capabilities of the effect in bioanalytics (100 references).
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subjects Animals
Cells - chemistry
Fluorescent Dyes - chemistry
Gold - chemistry
Humans
Metal Nanoparticles
Molecular Probes - chemistry
Silver - chemistry
Spectrum Analysis, Raman - methods
title SERS--a single-molecule and nanoscale tool for bioanalytics
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