Targeting of Human Retrotransposon Integration Is Directed by the Specificity of the L1 Endonuclease for Regions of Unusual DNA Structure

L1 elements are polyA retrotransposons which inhabit the human genome. Recent work has defined an endonuclease (L1 EN) encoded by the L1 element required for retrotransposition. We report the sequence specificity of this nicking endonuclease and the physical basis of its DNA recognition. L1 endonucl...

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Veröffentlicht in:	Biochemistry (Easton) 1998-12, Vol.37 (51), p.18081-18093
Hauptverfasser:	Cost, Gregory J, Boeke, Jef D
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Carbon-Oxygen Lyases - genetics Deoxyribonuclease IV (Phage T4-Induced) Dimethyl Sulfoxide - pharmacology DNA - chemistry DNA - drug effects DNA-(Apurinic or Apyrimidinic Site) Lyase Endonucleases - biosynthesis Endonucleases - genetics Endonucleases - isolation & purification Endonucleases - metabolism Genome, Human Humans Peptide Fragments - genetics Peptide Fragments - isolation & purification Peptide Fragments - metabolism Poly A - chemistry Poly T - chemistry Retroelements - drug effects Substrate Specificity
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