Long-term immunogenicity of a single dose of acellular pertussis vaccine in paediatric health-care workers
Summary Objective Monitor the long-term immunogenicity of a single dose of acellular pertussis vaccine in health-care workers. Design German health-care workers and child-care workers received a single dose of a monovalent acellular pertussis vaccine (PAC-Mérieux® ) in an open-label study. Blood sam...
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| Veröffentlicht in: | Vaccine 2008-05, Vol.26 (19), p.2344-2349 |
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| creator | Littmann, Martina Hülße, Christel Riffelmann, Marion Wirsing von König, Carl Heinz |
| description | Summary Objective Monitor the long-term immunogenicity of a single dose of acellular pertussis vaccine in health-care workers. Design German health-care workers and child-care workers received a single dose of a monovalent acellular pertussis vaccine (PAC-Mérieux® ) in an open-label study. Blood samples were taken before ( n = 261), 4 weeks after ( n = 246), 1 year ( n = 187), 2 years ( n = 53), 3 years ( n = 134) and 4 years ( n = 37) after vaccination. IgG- and IgA-anti-pertussis-toxin (PT), IgG- and IgA-anti-filamentous hemagglutinin (FHA), and IgG-anti-pertactin (PRN) were measured by ELISA. Results Of all subjects, 97.1%, 99.2% and 97.2% had an antibody response to PT, FHA and PRN, respectively. Four weeks after vaccination the median titres of IgG antibodies to PT, FHA and PRN were 314, 785 and 84 EU/l, respectively, and all vaccinees had an immune response to at least one pertussis antigen. IgA-anti-PT and IgA-anti-FHA responses were found in 63.4% and 96.3% of subjects with a median titre of 30 and 196 EU/ml, respectively. The titre of IgG-anti-PT decreased slowly with a median concentration of 76, 71, 71 and 63 EU/ml after 1, 2, 3 and 4 years, respectively. Secondary titre increases were observed in 0.5%, 3.3%, 5.6% and 12.5% of the vaccinees 1, 2, 3, and 4 years after vaccination. Conclusion In German health paediatric care workers long-lasting immune responses with high antibody levels could be induced by a single dose of acellular pertussis vaccine. A renewed contact with B. pertussis antigens resulted in a measurable immune response to PT between 0.5% (1 year p.v.) and 12.5% (4 years p.v.). |
| doi_str_mv | 10.1016/j.vaccine.2008.02.065 |
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Design German health-care workers and child-care workers received a single dose of a monovalent acellular pertussis vaccine (PAC-Mérieux® ) in an open-label study. Blood samples were taken before ( n = 261), 4 weeks after ( n = 246), 1 year ( n = 187), 2 years ( n = 53), 3 years ( n = 134) and 4 years ( n = 37) after vaccination. IgG- and IgA-anti-pertussis-toxin (PT), IgG- and IgA-anti-filamentous hemagglutinin (FHA), and IgG-anti-pertactin (PRN) were measured by ELISA. Results Of all subjects, 97.1%, 99.2% and 97.2% had an antibody response to PT, FHA and PRN, respectively. Four weeks after vaccination the median titres of IgG antibodies to PT, FHA and PRN were 314, 785 and 84 EU/l, respectively, and all vaccinees had an immune response to at least one pertussis antigen. IgA-anti-PT and IgA-anti-FHA responses were found in 63.4% and 96.3% of subjects with a median titre of 30 and 196 EU/ml, respectively. The titre of IgG-anti-PT decreased slowly with a median concentration of 76, 71, 71 and 63 EU/ml after 1, 2, 3 and 4 years, respectively. Secondary titre increases were observed in 0.5%, 3.3%, 5.6% and 12.5% of the vaccinees 1, 2, 3, and 4 years after vaccination. Conclusion In German health paediatric care workers long-lasting immune responses with high antibody levels could be induced by a single dose of acellular pertussis vaccine. A renewed contact with B. pertussis antigens resulted in a measurable immune response to PT between 0.5% (1 year p.v.) and 12.5% (4 years p.v.).</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2008.02.065</identifier><identifier>PMID: 18396360</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acellular vaccine ; Adhesins, Bacterial - immunology ; Adolescent ; Adult ; Age ; Allergy and Immunology ; Antibodies ; Antibodies, Bacterial - blood ; Antitoxins - blood ; Applied microbiology ; Bacterial diseases ; Bacterial Outer Membrane Proteins - immunology ; Biological and medical sciences ; Confidence intervals ; Ent and stomatologic bacterial diseases ; Enzyme-Linked Immunosorbent Assay ; Fundamental and applied biological sciences. Psychology ; Germany ; Health care ; Health Personnel ; Health-care workers ; Human bacterial diseases ; Humans ; Immune response ; Immune system ; Immunogenicity ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Infectious diseases ; Longitudinal Studies ; Medical sciences ; Microbiology ; Middle Aged ; Pertussis ; Pertussis Toxin - immunology ; Pertussis Vaccine - administration & dosage ; Pertussis Vaccine - immunology ; Statistical methods ; Studies ; Teenagers ; Toxins ; Vaccines ; Vaccines, Acellular - administration & dosage ; Vaccines, Acellular - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Virulence Factors, Bordetella - immunology ; Whooping cough</subject><ispartof>Vaccine, 2008-05, Vol.26 (19), p.2344-2349</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 2, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-ce0d64fd6cbb46cd879cd7f91e88f7525fd3ce00c0c1bec81fa363c070e1fd923</citedby><cites>FETCH-LOGICAL-c507t-ce0d64fd6cbb46cd879cd7f91e88f7525fd3ce00c0c1bec81fa363c070e1fd923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1558809512?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20297523$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18396360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Littmann, Martina</creatorcontrib><creatorcontrib>Hülße, Christel</creatorcontrib><creatorcontrib>Riffelmann, Marion</creatorcontrib><creatorcontrib>Wirsing von König, Carl Heinz</creatorcontrib><title>Long-term immunogenicity of a single dose of acellular pertussis vaccine in paediatric health-care workers</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Summary Objective Monitor the long-term immunogenicity of a single dose of acellular pertussis vaccine in health-care workers. Design German health-care workers and child-care workers received a single dose of a monovalent acellular pertussis vaccine (PAC-Mérieux® ) in an open-label study. Blood samples were taken before ( n = 261), 4 weeks after ( n = 246), 1 year ( n = 187), 2 years ( n = 53), 3 years ( n = 134) and 4 years ( n = 37) after vaccination. IgG- and IgA-anti-pertussis-toxin (PT), IgG- and IgA-anti-filamentous hemagglutinin (FHA), and IgG-anti-pertactin (PRN) were measured by ELISA. Results Of all subjects, 97.1%, 99.2% and 97.2% had an antibody response to PT, FHA and PRN, respectively. Four weeks after vaccination the median titres of IgG antibodies to PT, FHA and PRN were 314, 785 and 84 EU/l, respectively, and all vaccinees had an immune response to at least one pertussis antigen. IgA-anti-PT and IgA-anti-FHA responses were found in 63.4% and 96.3% of subjects with a median titre of 30 and 196 EU/ml, respectively. The titre of IgG-anti-PT decreased slowly with a median concentration of 76, 71, 71 and 63 EU/ml after 1, 2, 3 and 4 years, respectively. Secondary titre increases were observed in 0.5%, 3.3%, 5.6% and 12.5% of the vaccinees 1, 2, 3, and 4 years after vaccination. Conclusion In German health paediatric care workers long-lasting immune responses with high antibody levels could be induced by a single dose of acellular pertussis vaccine. A renewed contact with B. pertussis antigens resulted in a measurable immune response to PT between 0.5% (1 year p.v.) and 12.5% (4 years p.v.).</description><subject>Acellular vaccine</subject><subject>Adhesins, Bacterial - immunology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Allergy and Immunology</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antitoxins - blood</subject><subject>Applied microbiology</subject><subject>Bacterial diseases</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Biological and medical sciences</subject><subject>Confidence intervals</subject><subject>Ent and stomatologic bacterial diseases</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Germany</subject><subject>Health care</subject><subject>Health Personnel</subject><subject>Health-care workers</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunogenicity</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Pertussis</subject><subject>Pertussis Toxin - immunology</subject><subject>Pertussis Vaccine - administration & dosage</subject><subject>Pertussis Vaccine - immunology</subject><subject>Statistical methods</subject><subject>Studies</subject><subject>Teenagers</subject><subject>Toxins</subject><subject>Vaccines</subject><subject>Vaccines, Acellular - administration & dosage</subject><subject>Vaccines, Acellular - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Virulence Factors, Bordetella - immunology</subject><subject>Whooping cough</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk1r3DAQhk1paTZpf0KLoDQ3b0eyJUuXhhL6BQs9tIXehHY83mjjj61kp-y_r9w1DeSSk2B43tE7806WveKw5sDVu_36ziH6ntYCQK9BrEHJJ9mK66rIheT6abYCocq85PDrLDuPcQ8AsuDmeXbGdWFUoWCV7TdDv8tHCh3zXTf1w456j348sqFhjkXf71pi9RDpXwGpbafWBXagME4x-sgWG8z37OCo9m4MHtkNuXa8ydEFYn-GcEshvsieNa6N9HJ5L7Kfnz7-uP6Sb759_nr9YZOjhGrMkaBWZVMr3G5LhbWuDNZVYzhp3VRSyKYuEgMIyLeEmjeuUAVCBcSb2ojiIrs89T2E4fdEcbSdj7Nx19MwRasML40o5aOgAFNxoU0C3zwA98MU-jSE5VJqDUby-V95ojAMMQZq7CH4zoWj5WDnzOzeLsuyc2YWhE2ZJd3rpfu07ai-Vy0hJeDtAriIrm2C69HH_5wAYdJeisRdnThK273zFGxETz2mUALhaOvBP2rl_YMO2Pp0D669pSPF-6ltTAL7fT6w-b5AAwgNqvgLhDnNxg</recordid><startdate>20080502</startdate><enddate>20080502</enddate><creator>Littmann, Martina</creator><creator>Hülße, Christel</creator><creator>Riffelmann, Marion</creator><creator>Wirsing von König, Carl Heinz</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080502</creationdate><title>Long-term immunogenicity of a single dose of acellular pertussis vaccine in paediatric health-care workers</title><author>Littmann, Martina ; Hülße, Christel ; Riffelmann, Marion ; Wirsing von König, Carl Heinz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-ce0d64fd6cbb46cd879cd7f91e88f7525fd3ce00c0c1bec81fa363c070e1fd923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acellular vaccine</topic><topic>Adhesins, Bacterial - immunology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Allergy and Immunology</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antitoxins - blood</topic><topic>Applied microbiology</topic><topic>Bacterial diseases</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Biological and medical sciences</topic><topic>Confidence intervals</topic><topic>Ent and stomatologic bacterial diseases</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Germany</topic><topic>Health care</topic><topic>Health Personnel</topic><topic>Health-care workers</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunogenicity</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious diseases</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Pertussis</topic><topic>Pertussis Toxin - immunology</topic><topic>Pertussis Vaccine - administration & dosage</topic><topic>Pertussis Vaccine - immunology</topic><topic>Statistical methods</topic><topic>Studies</topic><topic>Teenagers</topic><topic>Toxins</topic><topic>Vaccines</topic><topic>Vaccines, Acellular - administration & dosage</topic><topic>Vaccines, Acellular - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Virulence Factors, Bordetella - immunology</topic><topic>Whooping cough</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Littmann, Martina</creatorcontrib><creatorcontrib>Hülße, Christel</creatorcontrib><creatorcontrib>Riffelmann, Marion</creatorcontrib><creatorcontrib>Wirsing von König, Carl Heinz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Littmann, Martina</au><au>Hülße, Christel</au><au>Riffelmann, Marion</au><au>Wirsing von König, Carl Heinz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term immunogenicity of a single dose of acellular pertussis vaccine in paediatric health-care workers</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2008-05-02</date><risdate>2008</risdate><volume>26</volume><issue>19</issue><spage>2344</spage><epage>2349</epage><pages>2344-2349</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Summary Objective Monitor the long-term immunogenicity of a single dose of acellular pertussis vaccine in health-care workers. Design German health-care workers and child-care workers received a single dose of a monovalent acellular pertussis vaccine (PAC-Mérieux® ) in an open-label study. Blood samples were taken before ( n = 261), 4 weeks after ( n = 246), 1 year ( n = 187), 2 years ( n = 53), 3 years ( n = 134) and 4 years ( n = 37) after vaccination. IgG- and IgA-anti-pertussis-toxin (PT), IgG- and IgA-anti-filamentous hemagglutinin (FHA), and IgG-anti-pertactin (PRN) were measured by ELISA. Results Of all subjects, 97.1%, 99.2% and 97.2% had an antibody response to PT, FHA and PRN, respectively. Four weeks after vaccination the median titres of IgG antibodies to PT, FHA and PRN were 314, 785 and 84 EU/l, respectively, and all vaccinees had an immune response to at least one pertussis antigen. IgA-anti-PT and IgA-anti-FHA responses were found in 63.4% and 96.3% of subjects with a median titre of 30 and 196 EU/ml, respectively. The titre of IgG-anti-PT decreased slowly with a median concentration of 76, 71, 71 and 63 EU/ml after 1, 2, 3 and 4 years, respectively. Secondary titre increases were observed in 0.5%, 3.3%, 5.6% and 12.5% of the vaccinees 1, 2, 3, and 4 years after vaccination. Conclusion In German health paediatric care workers long-lasting immune responses with high antibody levels could be induced by a single dose of acellular pertussis vaccine. A renewed contact with B. pertussis antigens resulted in a measurable immune response to PT between 0.5% (1 year p.v.) and 12.5% (4 years p.v.).</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18396360</pmid><doi>10.1016/j.vaccine.2008.02.065</doi><tpages>6</tpages></addata></record> |
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| subjects | Acellular vaccine Adhesins, Bacterial - immunology Adolescent Adult Age Allergy and Immunology Antibodies Antibodies, Bacterial - blood Antitoxins - blood Applied microbiology Bacterial diseases Bacterial Outer Membrane Proteins - immunology Biological and medical sciences Confidence intervals Ent and stomatologic bacterial diseases Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Germany Health care Health Personnel Health-care workers Human bacterial diseases Humans Immune response Immune system Immunogenicity Immunoglobulin A - blood Immunoglobulin G - blood Infectious diseases Longitudinal Studies Medical sciences Microbiology Middle Aged Pertussis Pertussis Toxin - immunology Pertussis Vaccine - administration & dosage Pertussis Vaccine - immunology Statistical methods Studies Teenagers Toxins Vaccines Vaccines, Acellular - administration & dosage Vaccines, Acellular - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virulence Factors, Bordetella - immunology Whooping cough |
| title | Long-term immunogenicity of a single dose of acellular pertussis vaccine in paediatric health-care workers |
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