HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias

Abstract We have analysed the expression of the HMGA2 gene in a panel of normal and neoplastic thyroid tissues by immunohistochemistry and quantitative RT-PCR. HMGA2 protein was detectable in four out of 21 follicular carcinomas, 30 out of 45 papillary carcinomas, and 11 out of 12 undifferentiated c...

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Veröffentlicht in:	European journal of cancer (1990) 2008-05, Vol.44 (7), p.1015-1021
Hauptverfasser:	Chiappetta, Gennaro, Ferraro, Angelo, Vuttariello, Emilia, Monaco, Mario, Galdiero, Francesca, De Simone, Veronica, Califano, Daniela, Pallante, Pierlorenzo, Botti, Gerardo, Pezzullo, Luciano, Pierantoni, Giovanna Maria, Santoro, Massimo, Fusco, Alfredo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Follicular - genetics Biological and medical sciences Carcinoma Carcinoma, Papillary - genetics Hematology, Oncology and Palliative Medicine HMGA2 HMGA2 Protein - genetics HMGA2 Protein - metabolism Humans Immunohistochemistry Medical sciences Pharmacology. Drug treatments Phenotype Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism RNA, Neoplasm - metabolism Thyroid carcinogenesis Thyroid Neoplasms - genetics Tumors
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