The role of nerve growth factor in hyperosmolar stress induced apoptosis

Nerve growth factor (NGF) is a neurotrophic factor that plays an important role in the differentiation and growth of neuronal cells. It is also regarded as an inflammatory mediator in non‐neuronal tissues under physiological stress conditions. The mechanisms of NGF production and its roles in hypero...

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Veröffentlicht in:	Journal of cellular physiology 2008-07, Vol.216 (1), p.69-77
Hauptverfasser:	Chang, Eun-Ju, Im, Young Sun, Kay, EunDuck P., Kim, Jong Youl, Lee, Jong Eun, Lee, Hyung Keun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Cornea - cytology Enzyme Inhibitors - metabolism Epithelial Cells - cytology Epithelial Cells - physiology Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation Humans Interleukin-1beta - genetics Interleukin-1beta - metabolism JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism MAP Kinase Signaling System - physiology Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism NF-kappa B - genetics NF-kappa B - metabolism Osmolar Concentration Phosphorylation Rats Rats, Sprague-Dawley Receptor, trkA - genetics Receptor, trkA - metabolism Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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