Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of nuclear factor-kappaB pathway

Atherosclerosis is a progressing inflammatory response mediated by various signaling molecules among which nuclear factor kappaB (NF-kappaB) is thought to have a pivotal role. This study demonstrated the efficacy of antioxidant MCI-186 in preventing the progression of atherosclerosis by inhibiting s...

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Veröffentlicht in:	Circulation journal : official journal of the Japanese Circulation Society 2008-05, Vol.72 (5), p.800-806
Hauptverfasser:	Radhakrishnan, Geethalakshmi, Suzuki, Ryoko, Maeda, Hironori, Yamamoto, Morio, Hirose, Nobuyuki, Gopalrao, Rajesh Katare, Lee, Gang-Hang, Hayashi, Yoshihiro, Rao, Parijatha, Sasaguri, Shiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioplasty, Balloon - adverse effects Animals Antioxidants - metabolism Antipyrine - analogs & derivatives Antipyrine - pharmacology Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology Carotid Artery Diseases - prevention & control Carotid Artery Injuries - metabolism Carotid Artery Injuries - pathology Carotid Artery, Common - metabolism Carotid Artery, Common - pathology Cholesterol - blood Disease Models, Animal Down-Regulation - drug effects E-Selectin - metabolism Edaravone Free Radical Scavengers - pharmacology Hyperplasia I-kappa B Proteins - metabolism Interleukin-1beta - pharmacology Male NF-kappa B - metabolism NF-KappaB Inhibitor alpha Rabbits Signal Transduction - drug effects Superoxides - metabolism Tunica Intima - metabolism Tunica Intima - pathology
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