Characterization of a subset of bone marrow-derived natural killer cells that regulates T cell activation in rats

We report that bone marrow‐derived natural killer (BMNK) cells from DA or F344 rats inhibit PMA/ionomycin‐induced T cell proliferation. These NK‐regulatory cells are NKR‐P1Adim, whereas a minor subpopulation is NKR‐P1Abright. Only the NKR‐P1Adim BMNK cells inhibit T cell proliferation. If activated...

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Veröffentlicht in:	Journal of leukocyte biology 2008-05, Vol.83 (5), p.1128-1135
Hauptverfasser:	Kheradmand, Taba, Trivedi, Prachi P., Wolf, Norbert A., Roberts, Paul C., Swanborg, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Cell Division cytokines Homeostasis Ionomycin - pharmacology Killer Cells, Natural - cytology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology omega-N-Methylarginine - pharmacology Rats Rats, Inbred F344 Rats, Sprague-Dawley suppression T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology Tissue Expansion tolerance
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