TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN

Antitumor effects of the toll-like receptor 7 (TLR7) agonist, 852A, were evaluated. Supernatants from human peripheral blood mononuclear cells (PBMC) stimulated with 852A inhibited the proliferation of tumor cell lines Hs294T and 769-P but had no effect on others (786-O and Caki-1). Because addition...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of interferon & cytokine research 2008-04, Vol.28 (4), p.253-263
Hauptverfasser:	Inglefield, Jon R, Dumitru, Calin Dan, Alkan, Sefik S, Gibson, Sheila J, Lipson, Kenneth E, Tomai, Mark A, Larson, Chris J, Vasilakos, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists (Biochemistry) Aminoquinolines - pharmacology Animals Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Culture Media, Conditioned - pharmacology Dendritic Cells - immunology Dosage and administration Drug therapy Health aspects Humans Interferon Interferon Type I - immunology Leukocytes, Mononuclear - drug effects Lung - drug effects Lung - pathology Melanoma - pathology Mice Neoplasms - pathology Oligodeoxyribonucleotides - pharmacology Quinolines - pharmacology Subcellular Fractions - drug effects Sulfonamides - pharmacology Toll-Like Receptor 7 - agonists Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!