Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium
This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression. Twenty eight adolescents with bipolar I disorder in a depressive episode received open-label lithium 30 mg/kg, adjusted to...
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| Veröffentlicht in: | Journal of child and adolescent psychopharmacology 2008-04, Vol.18 (2), p.132-139 |
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| creator | Patel, Nick C DelBello, Melissa P Cecil, Kim M Stanford, Kevin E Adler, Caleb M Strakowski, Stephen M |
| description | This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression.
Twenty eight adolescents with bipolar I disorder in a depressive episode received open-label lithium 30 mg/kg, adjusted to achieve serum levels of 1.0-1.2 mEq/L. Medial ventral and ventral lateral prefrontal NAA concentrations were measured at baseline, day 7, and day 42 of treatment. Temporal changes in NAA concentrations were analyzed and effect sizes (Cohen's d) were calculated.
Medial ventral prefrontal NAA concentrations decreased over time (p = 0.03), with day-42 concentrations significantly lower than baseline concentrations (p = 0.01, d = 0.7). No significant time effects on NAA concentrations were observed in the left (p = 0.2) or right ventral lateral (p = 0.3) prefrontal cortices.
In contrast with prior studies of bipolar adults, this study observes that ventral prefrontal NAA concentrations do not significantly increase from baseline following lithium treatment in adolescent bipolar depression. The results should be viewed in the context of the study's limitations, including the lack of a matched healthy control group. Additional longitudinal magnetic resonance imaging studies are warranted to understand better the role of NAA in the pathophysiology of bipolar disorder and neurochemical mechanisms by which lithium stabilizes mood. |
| doi_str_mv | 10.1089/cap.2007.0088 |
| format | Article |
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Twenty eight adolescents with bipolar I disorder in a depressive episode received open-label lithium 30 mg/kg, adjusted to achieve serum levels of 1.0-1.2 mEq/L. Medial ventral and ventral lateral prefrontal NAA concentrations were measured at baseline, day 7, and day 42 of treatment. Temporal changes in NAA concentrations were analyzed and effect sizes (Cohen's d) were calculated.
Medial ventral prefrontal NAA concentrations decreased over time (p = 0.03), with day-42 concentrations significantly lower than baseline concentrations (p = 0.01, d = 0.7). No significant time effects on NAA concentrations were observed in the left (p = 0.2) or right ventral lateral (p = 0.3) prefrontal cortices.
In contrast with prior studies of bipolar adults, this study observes that ventral prefrontal NAA concentrations do not significantly increase from baseline following lithium treatment in adolescent bipolar depression. The results should be viewed in the context of the study's limitations, including the lack of a matched healthy control group. Additional longitudinal magnetic resonance imaging studies are warranted to understand better the role of NAA in the pathophysiology of bipolar disorder and neurochemical mechanisms by which lithium stabilizes mood.</description><identifier>ISSN: 1044-5463</identifier><identifier>EISSN: 1557-8992</identifier><identifier>DOI: 10.1089/cap.2007.0088</identifier><identifier>PMID: 18439111</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adolescent ; Affect - drug effects ; Affect - physiology ; Amino acids ; Antimanic Agents - therapeutic use ; Aspartate ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Bipolar disorder ; Bipolar Disorder - blood ; Bipolar Disorder - drug therapy ; Bipolar Disorder - psychology ; Brain ; Child ; Child psychology ; Diagnosis ; Dominance, Cerebral - physiology ; Dosage and administration ; Drug therapy ; Female ; Follow-Up Studies ; Humans ; Image Processing, Computer-Assisted ; Lithium ; Lithium Compounds - pharmacokinetics ; Lithium Compounds - therapeutic use ; Magnetic Resonance Spectroscopy ; Male ; Mental depression ; Physiological aspects ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiopathology ; Psychopathology ; Software ; Teenagers</subject><ispartof>Journal of child and adolescent psychopharmacology, 2008-04, Vol.18 (2), p.132-139</ispartof><rights>COPYRIGHT 2008 Mary Ann Liebert, Inc.</rights><rights>(©) © 2008 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-bd81463875b2cfa6f081ab253e20c980e333a843ee500c80e64e90de09dab4c63</citedby><cites>FETCH-LOGICAL-c385t-bd81463875b2cfa6f081ab253e20c980e333a843ee500c80e64e90de09dab4c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18439111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Nick C</creatorcontrib><creatorcontrib>DelBello, Melissa P</creatorcontrib><creatorcontrib>Cecil, Kim M</creatorcontrib><creatorcontrib>Stanford, Kevin E</creatorcontrib><creatorcontrib>Adler, Caleb M</creatorcontrib><creatorcontrib>Strakowski, Stephen M</creatorcontrib><title>Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium</title><title>Journal of child and adolescent psychopharmacology</title><addtitle>J Child Adolesc Psychopharmacol</addtitle><description>This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression.
Twenty eight adolescents with bipolar I disorder in a depressive episode received open-label lithium 30 mg/kg, adjusted to achieve serum levels of 1.0-1.2 mEq/L. Medial ventral and ventral lateral prefrontal NAA concentrations were measured at baseline, day 7, and day 42 of treatment. Temporal changes in NAA concentrations were analyzed and effect sizes (Cohen's d) were calculated.
Medial ventral prefrontal NAA concentrations decreased over time (p = 0.03), with day-42 concentrations significantly lower than baseline concentrations (p = 0.01, d = 0.7). No significant time effects on NAA concentrations were observed in the left (p = 0.2) or right ventral lateral (p = 0.3) prefrontal cortices.
In contrast with prior studies of bipolar adults, this study observes that ventral prefrontal NAA concentrations do not significantly increase from baseline following lithium treatment in adolescent bipolar depression. The results should be viewed in the context of the study's limitations, including the lack of a matched healthy control group. Additional longitudinal magnetic resonance imaging studies are warranted to understand better the role of NAA in the pathophysiology of bipolar disorder and neurochemical mechanisms by which lithium stabilizes mood.</description><subject>Adolescent</subject><subject>Affect - drug effects</subject><subject>Affect - physiology</subject><subject>Amino acids</subject><subject>Antimanic Agents - therapeutic use</subject><subject>Aspartate</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - psychology</subject><subject>Brain</subject><subject>Child</subject><subject>Child psychology</subject><subject>Diagnosis</subject><subject>Dominance, Cerebral - physiology</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Lithium</subject><subject>Lithium Compounds - pharmacokinetics</subject><subject>Lithium Compounds - therapeutic use</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Mental depression</subject><subject>Physiological aspects</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychopathology</subject><subject>Software</subject><subject>Teenagers</subject><issn>1044-5463</issn><issn>1557-8992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkduL1TAQxoMo7nr00VcpCr71OGl6SR6XxRss-rI-h2k63c3SNjVJkf3vnXIOiCKBXH_z8WU-IV5LOErQ5oPD9VgBdEcArZ-IS9k0XamNqZ7yHuq6bOpWXYgXKT0ASNVC-1xcSF0rI6W8FOstzWuIOBXuHpc7KvxSfCvRUX6cSkwrxoyZChcWR0uOmH1Y0g7hECZK-2Uqfvl8X_R-DRPGYqA1UkrMFTkSFw-n94knv80vxbMRp0SvzutB_Pj08fb6S3nz_fPX66ub0ind5LIftGTjumv6yo3YjqAl9lWjqAJnNJBSCvkXRA2A43Nbk4GBwAzY165VB_H-pLvG8HOjlO3s2e404UJhS7Y1rL_34SDe_gM-hC0u7M1WwBZA1pKhdyfoDieyfhkD98LtivZKdqZTbdXsUsf_UDwGmj23kEbP938VlKcCF0NKkUa7Rj9jfLQS7B6v5XjtHq_d42X-zdnr1s80_KHPearfirSgWA</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Patel, Nick C</creator><creator>DelBello, Melissa P</creator><creator>Cecil, Kim M</creator><creator>Stanford, Kevin E</creator><creator>Adler, Caleb M</creator><creator>Strakowski, Stephen M</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium</title><author>Patel, Nick C ; DelBello, Melissa P ; Cecil, Kim M ; Stanford, Kevin E ; Adler, Caleb M ; Strakowski, Stephen M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-bd81463875b2cfa6f081ab253e20c980e333a843ee500c80e64e90de09dab4c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Affect - drug effects</topic><topic>Affect - physiology</topic><topic>Amino acids</topic><topic>Antimanic Agents - therapeutic use</topic><topic>Aspartate</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - psychology</topic><topic>Brain</topic><topic>Child</topic><topic>Child psychology</topic><topic>Diagnosis</topic><topic>Dominance, Cerebral - physiology</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Lithium</topic><topic>Lithium Compounds - pharmacokinetics</topic><topic>Lithium Compounds - therapeutic use</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Mental depression</topic><topic>Physiological aspects</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychopathology</topic><topic>Software</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Nick C</creatorcontrib><creatorcontrib>DelBello, Melissa P</creatorcontrib><creatorcontrib>Cecil, Kim M</creatorcontrib><creatorcontrib>Stanford, Kevin E</creatorcontrib><creatorcontrib>Adler, Caleb M</creatorcontrib><creatorcontrib>Strakowski, Stephen M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of child and adolescent psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Nick C</au><au>DelBello, Melissa P</au><au>Cecil, Kim M</au><au>Stanford, Kevin E</au><au>Adler, Caleb M</au><au>Strakowski, Stephen M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium</atitle><jtitle>Journal of child and adolescent psychopharmacology</jtitle><addtitle>J Child Adolesc Psychopharmacol</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>18</volume><issue>2</issue><spage>132</spage><epage>139</epage><pages>132-139</pages><issn>1044-5463</issn><eissn>1557-8992</eissn><abstract>This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression.
Twenty eight adolescents with bipolar I disorder in a depressive episode received open-label lithium 30 mg/kg, adjusted to achieve serum levels of 1.0-1.2 mEq/L. Medial ventral and ventral lateral prefrontal NAA concentrations were measured at baseline, day 7, and day 42 of treatment. Temporal changes in NAA concentrations were analyzed and effect sizes (Cohen's d) were calculated.
Medial ventral prefrontal NAA concentrations decreased over time (p = 0.03), with day-42 concentrations significantly lower than baseline concentrations (p = 0.01, d = 0.7). No significant time effects on NAA concentrations were observed in the left (p = 0.2) or right ventral lateral (p = 0.3) prefrontal cortices.
In contrast with prior studies of bipolar adults, this study observes that ventral prefrontal NAA concentrations do not significantly increase from baseline following lithium treatment in adolescent bipolar depression. The results should be viewed in the context of the study's limitations, including the lack of a matched healthy control group. Additional longitudinal magnetic resonance imaging studies are warranted to understand better the role of NAA in the pathophysiology of bipolar disorder and neurochemical mechanisms by which lithium stabilizes mood.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>18439111</pmid><doi>10.1089/cap.2007.0088</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Affect - drug effects Affect - physiology Amino acids Antimanic Agents - therapeutic use Aspartate Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Bipolar disorder Bipolar Disorder - blood Bipolar Disorder - drug therapy Bipolar Disorder - psychology Brain Child Child psychology Diagnosis Dominance, Cerebral - physiology Dosage and administration Drug therapy Female Follow-Up Studies Humans Image Processing, Computer-Assisted Lithium Lithium Compounds - pharmacokinetics Lithium Compounds - therapeutic use Magnetic Resonance Spectroscopy Male Mental depression Physiological aspects Prefrontal Cortex - drug effects Prefrontal Cortex - physiopathology Psychopathology Software Teenagers |
| title | Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium |
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