Prognostic factors in bone marrow transplantation for beta thalassemia major : experiences from Iran
This study concerns the effects of several pre-transplant features on outcome for patients with beta thalassemia major who underwent bone marrow transplantation (BMT). Seventy patients with beta thalassemia major underwent bone marrow transplantation during the period 1991-1997 in Shariati Hospital...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 1998-12, Vol.22 (12), p.1167-1169 |
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| creator | GHAVAMZADEH, A NASSERI, P ESHRAGHIAN, M. R JAHANI, M BAYBORDI, I NATEGHI, J KHODABANDEH, A SADJADI, A. R MOHYEDDIN, M KHADEMI, Y |
| description | This study concerns the effects of several pre-transplant features on outcome for patients with beta thalassemia major who underwent bone marrow transplantation (BMT). Seventy patients with beta thalassemia major underwent bone marrow transplantation during the period 1991-1997 in Shariati Hospital in Tehran, Iran. The survival and rejection curves levelled off at 8 and 18 months after transplantation at 82.6% and 11.4%, respectively. Pre-transplant clinical features (age, serum ferritin, portal fibrosis, hepatomegaly and quality of chelation therapy) were examined for their effects on survival and recurrence of thalassemia in this group of patients who were less than 16 years old. Increasing age, presence of portal fibrosis and increasing serum ferritin were significantly associated with reduced probability of survival (P = 0.0047, P = 0.016 and P = 0.024, respectively). Hepatomegaly and inadequate pre-transplant chelation therapy which were documented as poor prognostic factors in previous studies, were not evaluable in this study. We also showed the benefits of transplanting more than 5.5 x 10(8)/kg cells in this group of patients with no increase in complications. |
| doi_str_mv | 10.1038/sj.bmt.1701509 |
| format | Article |
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R ; JAHANI, M ; BAYBORDI, I ; NATEGHI, J ; KHODABANDEH, A ; SADJADI, A. R ; MOHYEDDIN, M ; KHADEMI, Y</creator><creatorcontrib>GHAVAMZADEH, A ; NASSERI, P ; ESHRAGHIAN, M. R ; JAHANI, M ; BAYBORDI, I ; NATEGHI, J ; KHODABANDEH, A ; SADJADI, A. R ; MOHYEDDIN, M ; KHADEMI, Y</creatorcontrib><description>This study concerns the effects of several pre-transplant features on outcome for patients with beta thalassemia major who underwent bone marrow transplantation (BMT). Seventy patients with beta thalassemia major underwent bone marrow transplantation during the period 1991-1997 in Shariati Hospital in Tehran, Iran. The survival and rejection curves levelled off at 8 and 18 months after transplantation at 82.6% and 11.4%, respectively. Pre-transplant clinical features (age, serum ferritin, portal fibrosis, hepatomegaly and quality of chelation therapy) were examined for their effects on survival and recurrence of thalassemia in this group of patients who were less than 16 years old. Increasing age, presence of portal fibrosis and increasing serum ferritin were significantly associated with reduced probability of survival (P = 0.0047, P = 0.016 and P = 0.024, respectively). Hepatomegaly and inadequate pre-transplant chelation therapy which were documented as poor prognostic factors in previous studies, were not evaluable in this study. We also showed the benefits of transplanting more than 5.5 x 10(8)/kg cells in this group of patients with no increase in complications.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1701509</identifier><identifier>PMID: 9894719</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adolescent ; Age Factors ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; beta-Thalassemia - therapy ; Biological and medical sciences ; Blood diseases ; Bone marrow ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Chelation ; Chelation therapy ; Child ; Child, Preschool ; Complications ; Female ; Ferritin ; Ferritins - blood ; Fibrosis ; Graft Rejection ; Graft Survival ; Humans ; Iran ; Male ; Medical prognosis ; Medical sciences ; Patients ; Prognosis ; Risk Factors ; Stem cell transplantation ; Survival ; Thalassemia ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Tropical medicine</subject><ispartof>Bone marrow transplantation (Basingstoke), 1998-12, Vol.22 (12), p.1167-1169</ispartof><rights>1999 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1998.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-920e38b2a56102bdd4175e84e048ba4aa70aa6570197e2e96d0b172b126840893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1621874$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9894719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GHAVAMZADEH, A</creatorcontrib><creatorcontrib>NASSERI, P</creatorcontrib><creatorcontrib>ESHRAGHIAN, M. R</creatorcontrib><creatorcontrib>JAHANI, M</creatorcontrib><creatorcontrib>BAYBORDI, I</creatorcontrib><creatorcontrib>NATEGHI, J</creatorcontrib><creatorcontrib>KHODABANDEH, A</creatorcontrib><creatorcontrib>SADJADI, A. R</creatorcontrib><creatorcontrib>MOHYEDDIN, M</creatorcontrib><creatorcontrib>KHADEMI, Y</creatorcontrib><title>Prognostic factors in bone marrow transplantation for beta thalassemia major : experiences from Iran</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>This study concerns the effects of several pre-transplant features on outcome for patients with beta thalassemia major who underwent bone marrow transplantation (BMT). Seventy patients with beta thalassemia major underwent bone marrow transplantation during the period 1991-1997 in Shariati Hospital in Tehran, Iran. The survival and rejection curves levelled off at 8 and 18 months after transplantation at 82.6% and 11.4%, respectively. Pre-transplant clinical features (age, serum ferritin, portal fibrosis, hepatomegaly and quality of chelation therapy) were examined for their effects on survival and recurrence of thalassemia in this group of patients who were less than 16 years old. Increasing age, presence of portal fibrosis and increasing serum ferritin were significantly associated with reduced probability of survival (P = 0.0047, P = 0.016 and P = 0.024, respectively). Hepatomegaly and inadequate pre-transplant chelation therapy which were documented as poor prognostic factors in previous studies, were not evaluable in this study. We also showed the benefits of transplanting more than 5.5 x 10(8)/kg cells in this group of patients with no increase in complications.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>beta-Thalassemia - therapy</subject><subject>Biological and medical sciences</subject><subject>Blood diseases</subject><subject>Bone marrow</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Chelation</subject><subject>Chelation therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Complications</subject><subject>Female</subject><subject>Ferritin</subject><subject>Ferritins - blood</subject><subject>Fibrosis</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Iran</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Stem cell transplantation</subject><subject>Survival</subject><subject>Thalassemia</subject><subject>Transfusions. Complications. Transfusion reactions. 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Graft versus host reaction</topic><topic>Chelation</topic><topic>Chelation therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Complications</topic><topic>Female</topic><topic>Ferritin</topic><topic>Ferritins - blood</topic><topic>Fibrosis</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Iran</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Stem cell transplantation</topic><topic>Survival</topic><topic>Thalassemia</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GHAVAMZADEH, A</creatorcontrib><creatorcontrib>NASSERI, P</creatorcontrib><creatorcontrib>ESHRAGHIAN, M. 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The survival and rejection curves levelled off at 8 and 18 months after transplantation at 82.6% and 11.4%, respectively. Pre-transplant clinical features (age, serum ferritin, portal fibrosis, hepatomegaly and quality of chelation therapy) were examined for their effects on survival and recurrence of thalassemia in this group of patients who were less than 16 years old. Increasing age, presence of portal fibrosis and increasing serum ferritin were significantly associated with reduced probability of survival (P = 0.0047, P = 0.016 and P = 0.024, respectively). Hepatomegaly and inadequate pre-transplant chelation therapy which were documented as poor prognostic factors in previous studies, were not evaluable in this study. 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| subjects | Adolescent Age Factors Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy beta-Thalassemia - therapy Biological and medical sciences Blood diseases Bone marrow Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Chelation Chelation therapy Child Child, Preschool Complications Female Ferritin Ferritins - blood Fibrosis Graft Rejection Graft Survival Humans Iran Male Medical prognosis Medical sciences Patients Prognosis Risk Factors Stem cell transplantation Survival Thalassemia Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Tropical medicine |
| title | Prognostic factors in bone marrow transplantation for beta thalassemia major : experiences from Iran |
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