An inhibitor of inducible nitric oxide synthase ameliorates experimental autoimmune myocarditis in Lewis rats

We studied the effect of nitric oxide (NO) on experimental autoimmune myocarditis (EAC) in rats. We examined the role of inducible nitric oxide synthase (iNOS), an enzyme that produces NO, on hearts affected with EAC, by testing the effects of aminoguanidine (AG), a selective iNOS inhibitor, on the...

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Veröffentlicht in:	Journal of neuroimmunology 1998-12, Vol.92 (1), p.133-138
Hauptverfasser:	Shin, Taekyun, Tanuma, Naoyuki, Kim, Seungjoon, Jin, Jaekwang, Moon, Changjong, Kim, Kiok, Kohyama, Kuniko, Matsumoto, Yoh, Hyun, Byunghwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoguanidine Animals Autoimmune Diseases - enzymology Autoimmune Diseases - pathology Autoimmune Diseases - prevention & control Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Experimental autoimmune myocarditis Guanidines - pharmacology Myocarditis - enzymology Myocarditis - pathology Myocarditis - prevention & control Myocardium - enzymology Myocardium - metabolism Myocardium - pathology Nitric oxide synthase Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Rats Rats, Inbred Lew Tyrosine - analogs & derivatives Tyrosine - metabolism
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