Erinacine E as a Kappa Opioid Receptor Agonist and Its New Analogs from a Basidiomycete, Hericium ramosum

A κ opioid receptor binding inhibitor was isolated from the fermentation broth of a basidiomycete, Hericium ramosum CL24240 and identified as erinacine E (1). Three analogs of 1 were produced by fermentation in other media and by microbial biotransformation. Of these compounds, 1 was shown to be the...

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Veröffentlicht in:	Journal of antibiotics 1998/11/25, Vol.51(11), pp.983-990
Hauptverfasser:	SAITO, TOSHIYUKI, AOKI, FUKUMATSU, HIRAI, HIDEO, INAGAKI, TAISUKE, MATSUNAGA, YASUE, SAKAKIBARA, TATSUO, SAKEMI, SHINICHI, SUZUKI, YUMIKO, WATANABE, SHUZO, SUGA, OSAMU, SUJAKU, TETSUJO, SMOGOWICZ, ADAM A., TRUESDELL, SUSAN J., WONG, JOHN W., NAGAHISA, ATSUSHI, KOJIMA, YASUHIRO, KOJIMA, NAKAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basidiomycota Benzofurans - chemistry Benzofurans - isolation & purification Benzofurans - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid Electric Stimulation Fermentation Guinea Pigs Hericium ramosum Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Rabbits Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - metabolism Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology Structure-Activity Relationship Vas Deferens - drug effects Vas Deferens - metabolism
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