The human spleen is a major reservoir for long-lived vaccinia virus–specific memory B cells

The fact that you can vaccinate a child at 5 years of age and find lymphoid B cells and antibodies specific for this vaccination 70 years later remains an immunologic enigma. It has never been determined how these long-lived memory B cells are maintained and whether they are protected by storage in...

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Veröffentlicht in:	Blood 2008-05, Vol.111 (9), p.4653-4659
Hauptverfasser:	Mamani-Matsuda, Maria, Cosma, Antonio, Weller, Sandra, Faili, Ahmad, Staib, Caroline, Garçon, Loïc, Hermine, Olivier, Beyne-Rauzy, Odile, Fieschi, Claire, Pers, Jacques-Olivier, Arakelyan, Nina, Varet, Bruno, Sauvanet, Alain, Berger, Anne, Paye, François, Andrieu, Jean-Marie, Michel, Marc, Godeau, Bertrand, Buffet, Pierre, Reynaud, Claude-Agnès, Weill, Jean-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - immunology B-Lymphocytes - virology Biological and medical sciences Case-Control Studies Fundamental and applied biological sciences. Psychology Humans Immunoglobulin G Immunologic Memory Microbiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Spleen - cytology Spleen - immunology Splenectomy Vaccinia virus - immunology Virology
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