Na(+)/Ca(2+) exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart

The Na(+)/Ca(2+) exchanger (NCX) may play a key role in myocardial contractility. The operation of the NCX is affected by the action potential (AP) configuration and the intracellular Na(+) concentration. This study examined the effect of selective NCX inhibition by 0.1, 0.3 and 1.0 microM SEA0400 o...

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Veröffentlicht in:	British journal of pharmacology 2008-05, Vol.154 (1), p.93-104
Hauptverfasser:	Farkas, A S, Acsai, K, Nagy, N, Tóth, A, Fülöp, F, Seprényi, G, Birinyi, P, Nánási, P P, Forster, T, Csanády, M, Papp, J G, Varró, A, Farkas, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Aniline Compounds - pharmacology Animals Blood Pressure - drug effects Cardiotonic Agents - pharmacology Coronary Circulation - drug effects Electrocardiography - drug effects Heart - drug effects Heart Rate - drug effects Immunohistochemistry Microscopy, Confocal Myocardial Contraction - drug effects Myocytes, Cardiac - drug effects Patch-Clamp Techniques Phenyl Ethers - pharmacology Rabbits Rats Sodium-Calcium Exchanger - antagonists & inhibitors Species Specificity
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