Oncostatin M induction of eotaxin-1 expression requires the convergence of PI3'K and ERK1/2 MAPK signal transduction pathways

Oncostatin M (OSM) is an IL-6/LIF cytokine family member whose role has been identified in a range of biological activities in vitro, including upregulation of inflammatory gene expression and regulation of connective tissue metabolism. Previously, we identified murine OSM (mOSM) as an inducer of th...

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Veröffentlicht in:	Cellular signalling 2008-06, Vol.20 (6), p.1142-1150
Hauptverfasser:	Smyth, David C, Kerr, Christine, Li, Yanxia, Tang, Damu, Richards, Carl D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemokine CCL11 - biosynthesis Chemokine CCL11 - genetics Chromones - pharmacology Enzyme Inhibitors - pharmacology Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - metabolism Flavonoids - pharmacology Gene Expression - drug effects MAP Kinase Signaling System - drug effects Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Morpholines - pharmacology NIH 3T3 Cells Oncostatin M - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Protein Kinase C-delta - antagonists & inhibitors Protein Kinase C-delta - genetics Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-jun - metabolism RNA Interference Signal Transduction - drug effects Transcription Factor AP-1 - metabolism
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