Pharmacokinetic-Pharmacodynamic Modeling of Morphine and Oxycodone Concentrations and Analgesic Effect in a Multimodal Experimental Pain Model

Analgesia from most opioids is mediated by μ receptors located mainly in the central nervous system. Previous studies have shown a different pharmacological profile of oxycodone in respect to visceral analgesia. This study investigated if morphine and oxycodone have different pharmacokinetic/pharmac...

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Veröffentlicht in:	Journal of clinical pharmacology 2008-05, Vol.48 (5), p.619-631
Hauptverfasser:	Staahl, Camilla, Upton, Richard, Foster, David J. R., Christrup, Lona Louring, Kristensen, Kim, Hansen, Steen Honoré, Arendt-Nielsen, Lars, Drewes, Asbjørn Mohr
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Algorithms Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - pharmacology Area Under Curve Cross-Over Studies Dosage and administration Dose-Response Relationship, Drug Double-Blind Method Electric Stimulation - adverse effects Experimental pain Female Hot Temperature - adverse effects Humans Infusions, Parenteral Male Models, Biological Morphine Morphine - administration & dosage Morphine - pharmacokinetics Morphine - pharmacology Oxycodone Oxycodone - administration & dosage Oxycodone - pharmacokinetics Oxycodone - pharmacology Pain - drug therapy Pain - etiology Pain Measurement - drug effects Pain Threshold - drug effects pharmaco kinetics pharmacodynamics Pharmacokinetics Physical Stimulation - adverse effects Physical Stimulation - methods Properties
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