The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum

The phytocannabinoid Delta(9)-tetrahydrocannabivarin (Delta(9)-THCV) has been reported to exhibit a diverse pharmacology; here, we investigate functional effects of Delta(9)-THCV, extracted from Cannabis sativa, using electrophysiological techniques to define its mechanism of action in the CNS. Effe...

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Veröffentlicht in:	British journal of pharmacology 2008-05, Vol.154 (1), p.204-215
Hauptverfasser:	Ma, Y-L, Weston, S E, Whalley, B J, Stephens, G J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoxazines - pharmacology Bicuculline - pharmacology Cannabinoids - pharmacology Cerebellum - drug effects Dronabinol - analogs & derivatives Dronabinol - antagonists & inhibitors Dronabinol - pharmacology Electrophysiology Excitatory Postsynaptic Potentials - drug effects GABA Antagonists - pharmacology gamma-Aminobutyric Acid - physiology In Vitro Techniques Male Mice Morpholines - pharmacology Naphthalenes - pharmacology Patch-Clamp Techniques Piperidines - pharmacology Purkinje Cells - drug effects Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - antagonists & inhibitors Rimonabant Synapses - drug effects Synaptic Transmission - drug effects
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