Endothelial Arginase II: A Novel Target for the Treatment of Atherosclerosis

Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E–null (ApoE) and wild-type mice fed a high chole...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2008-04, Vol.102 (8), p.923-932
Hauptverfasser:	Ryoo, Sungwoo, Gupta, Gaurav, Benjo, Alexandre, Lim, Hyun Kyo, Camara, Andre, Sikka, Gautam, Lim, Hyun Kyung, Sohi, Jayson, Santhanam, Lakshmi, Soucy, Kevin, Tuday, Eric, Baraban, Ezra, Ilies, Monica, Gerstenblith, Gary, Nyhan, Daniel, Shoukas, Artin, Christianson, David W, Alp, Nicholas J, Champion, Hunter C, Huso, David, Berkowitz, Dan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - deficiency Arginase - antagonists & inhibitors Arginase - genetics Arginase - physiology Atherosclerosis (general aspects, experimental research) Atherosclerosis - etiology Atherosclerosis - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol - administration & dosage Endothelial Cells - pathology Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Fundamental and applied biological sciences. Psychology Medical sciences Mice Mice, Knockout Nitric Oxide - biosynthesis Nitric Oxide Synthase Type III Up-Regulation Vascular Resistance Vertebrates: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!