Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

Background: The actin-related proteins Arp2 and Arp3 are part of a seven-protein complex which is localized in the lamellipodia of a variety of cell types, and in actin-rich spots of unknown function. The Arp2/3 complex enhances actin nucleation and causes branching and crosslinking of actin filamen...

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Veröffentlicht in:	Current biology 1998-12, Vol.8 (25), p.1347-1356
Hauptverfasser:	Machesky, Laura M., Insall, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Actin-Related Protein 2 Actin-Related Protein 3 Actins - metabolism Animals Brain Chemistry COS Cells Cytoskeletal Proteins Cytoskeleton - metabolism Cytosol - metabolism Gene Expression Regulation Growth Substances - physiology Mice Microfilament Proteins Protein Binding - physiology Protein Biosynthesis Proteins - genetics Proteins - metabolism Proteins - physiology Rabbits Swine Wiskott-Aldrich Syndrome Protein Wiskott-Aldrich Syndrome Protein Family
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