Structural characteristics of low-molecular-mass displacers for cation-exchange chromatography: II. Role of the stationary phase
The relative efficacy of a variety of low-molecular-mass displacers was examined on three different stationary phase materials. Several homologous series of displacer molecules were evaluated on these ion- exchange resins using a displacer ranking plot based on the steric mass action model. The resu...
Gespeichert in:
| Veröffentlicht in: | Journal of Chromatography A 1998-12, Vol.827 (2), p.295-310 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 310 |
|---|---|
| container_issue | 2 |
| container_start_page | 295 |
| container_title | Journal of Chromatography A |
| container_volume | 827 |
| creator | Shukla, Abhinav A. Bae, Sung Su Moore, J.A. Cramer, Steven M. |
| description | The relative efficacy of a variety of low-molecular-mass displacers was examined on three different stationary phase materials. Several homologous series of displacer molecules were evaluated on these ion- exchange resins using a displacer ranking plot based on the steric mass action model. The results demonstrate that while aromaticity and hydrophobicity can play a significant role in the affinity of displacer molecules on polymethacrylate based and hydrophilized polystyrene–divinylbenzene based materials, this effect is much less pronounced on an agarose based resin. The work presented in this paper demonstrates that different structural features of low-molecular-mass displacers can dominate their affinity on various stationary phase materials employed and provides rules of thumb for the design of high affinity, low-molecular-mass displacers for a variety of commercial cation-exchange materials. |
| doi_str_mv | 10.1016/S0021-9673(98)00805-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69139810</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S002196739800805X</els_id><sourcerecordid>69139810</sourcerecordid><originalsourceid>FETCH-LOGICAL-e223t-ba8073a83d2e7dbdfda8c1fa20ed2a9d220b1e1b0c1c13083b9e148d98bf00733</originalsourceid><addsrcrecordid>eNo9kU9v1DAQxX0AtaXlI1TyASE4pPjPNrG5oKqisFKlSpRKvVkTe9I1cuJgO0Bv_eh4t6ueRpr5vaeZeYSccnbGGW8_3TImeKPbTn7Q6iNjip0396_I0Uv7kLzJ-RdjvGOdOCAHWvNVe94dkafbkhZblgSB2g0ksAWTz8XbTONAQ_zbjDGgXQKkZoScqfN5DmAxZTrERC0UH6cG_1X19IDVJMURSnxIMG8eP9P1-oz-qA5bt7JBmstOAOmRzhvIeEJeDxAyvt3XY3J39fXn5ffm-ubb-vLiukEhZGl6UKyToKQT2LneDQ6U5QMIhk6AdkKwniPvmeWWS6Zkr5GvlNOqH1hVymPy_tl3TvH3grmY0WeLIcCEccmm1VxqxVkFT_fg0o_ozJz8WLc1-5fV-bv9HLKFMCSYrM8vGG_VqhW6Yl-eMaxH_fGYTLYeJ4vOJ7TFuOgNZ2Ybn9nFZ7Y5Ga3MLj5zL_8D1fiRCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69139810</pqid></control><display><type>article</type><title>Structural characteristics of low-molecular-mass displacers for cation-exchange chromatography: II. Role of the stationary phase</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Shukla, Abhinav A. ; Bae, Sung Su ; Moore, J.A. ; Cramer, Steven M.</creator><creatorcontrib>Shukla, Abhinav A. ; Bae, Sung Su ; Moore, J.A. ; Cramer, Steven M.</creatorcontrib><description>The relative efficacy of a variety of low-molecular-mass displacers was examined on three different stationary phase materials. Several homologous series of displacer molecules were evaluated on these ion- exchange resins using a displacer ranking plot based on the steric mass action model. The results demonstrate that while aromaticity and hydrophobicity can play a significant role in the affinity of displacer molecules on polymethacrylate based and hydrophilized polystyrene–divinylbenzene based materials, this effect is much less pronounced on an agarose based resin. The work presented in this paper demonstrates that different structural features of low-molecular-mass displacers can dominate their affinity on various stationary phase materials employed and provides rules of thumb for the design of high affinity, low-molecular-mass displacers for a variety of commercial cation-exchange materials.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/S0021-9673(98)00805-X</identifier><identifier>PMID: 9914657</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amines ; Analytical biochemistry: general aspects, technics, instrumentation ; Analytical chemistry ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Biotechnology ; Cation Exchange Resins ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, Ion Exchange - methods ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; Magnetic Resonance Spectroscopy ; Methods. Procedures. Technologies ; Molecular Structure ; Other chromatographic methods ; Others ; Spectrophotometry, Ultraviolet ; Various methods and equipments</subject><ispartof>Journal of Chromatography A, 1998-12, Vol.827 (2), p.295-310</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0021-9673(98)00805-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,778,782,787,788,3539,23913,23914,25123,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1684629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9914657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shukla, Abhinav A.</creatorcontrib><creatorcontrib>Bae, Sung Su</creatorcontrib><creatorcontrib>Moore, J.A.</creatorcontrib><creatorcontrib>Cramer, Steven M.</creatorcontrib><title>Structural characteristics of low-molecular-mass displacers for cation-exchange chromatography: II. Role of the stationary phase</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>The relative efficacy of a variety of low-molecular-mass displacers was examined on three different stationary phase materials. Several homologous series of displacer molecules were evaluated on these ion- exchange resins using a displacer ranking plot based on the steric mass action model. The results demonstrate that while aromaticity and hydrophobicity can play a significant role in the affinity of displacer molecules on polymethacrylate based and hydrophilized polystyrene–divinylbenzene based materials, this effect is much less pronounced on an agarose based resin. The work presented in this paper demonstrates that different structural features of low-molecular-mass displacers can dominate their affinity on various stationary phase materials employed and provides rules of thumb for the design of high affinity, low-molecular-mass displacers for a variety of commercial cation-exchange materials.</description><subject>Amines</subject><subject>Analytical biochemistry: general aspects, technics, instrumentation</subject><subject>Analytical chemistry</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cation Exchange Resins</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, Ion Exchange - methods</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Methods. Procedures. Technologies</subject><subject>Molecular Structure</subject><subject>Other chromatographic methods</subject><subject>Others</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Various methods and equipments</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU9v1DAQxX0AtaXlI1TyASE4pPjPNrG5oKqisFKlSpRKvVkTe9I1cuJgO0Bv_eh4t6ueRpr5vaeZeYSccnbGGW8_3TImeKPbTn7Q6iNjip0396_I0Uv7kLzJ-RdjvGOdOCAHWvNVe94dkafbkhZblgSB2g0ksAWTz8XbTONAQ_zbjDGgXQKkZoScqfN5DmAxZTrERC0UH6cG_1X19IDVJMURSnxIMG8eP9P1-oz-qA5bt7JBmstOAOmRzhvIeEJeDxAyvt3XY3J39fXn5ffm-ubb-vLiukEhZGl6UKyToKQT2LneDQ6U5QMIhk6AdkKwniPvmeWWS6Zkr5GvlNOqH1hVymPy_tl3TvH3grmY0WeLIcCEccmm1VxqxVkFT_fg0o_ozJz8WLc1-5fV-bv9HLKFMCSYrM8vGG_VqhW6Yl-eMaxH_fGYTLYeJ4vOJ7TFuOgNZ2Ybn9nFZ7Y5Ga3MLj5zL_8D1fiRCw</recordid><startdate>19981211</startdate><enddate>19981211</enddate><creator>Shukla, Abhinav A.</creator><creator>Bae, Sung Su</creator><creator>Moore, J.A.</creator><creator>Cramer, Steven M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19981211</creationdate><title>Structural characteristics of low-molecular-mass displacers for cation-exchange chromatography: II. Role of the stationary phase</title><author>Shukla, Abhinav A. ; Bae, Sung Su ; Moore, J.A. ; Cramer, Steven M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e223t-ba8073a83d2e7dbdfda8c1fa20ed2a9d220b1e1b0c1c13083b9e148d98bf00733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amines</topic><topic>Analytical biochemistry: general aspects, technics, instrumentation</topic><topic>Analytical chemistry</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cation Exchange Resins</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, Ion Exchange - methods</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Methods. Procedures. Technologies</topic><topic>Molecular Structure</topic><topic>Other chromatographic methods</topic><topic>Others</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Various methods and equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shukla, Abhinav A.</creatorcontrib><creatorcontrib>Bae, Sung Su</creatorcontrib><creatorcontrib>Moore, J.A.</creatorcontrib><creatorcontrib>Cramer, Steven M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shukla, Abhinav A.</au><au>Bae, Sung Su</au><au>Moore, J.A.</au><au>Cramer, Steven M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural characteristics of low-molecular-mass displacers for cation-exchange chromatography: II. Role of the stationary phase</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>1998-12-11</date><risdate>1998</risdate><volume>827</volume><issue>2</issue><spage>295</spage><epage>310</epage><pages>295-310</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>The relative efficacy of a variety of low-molecular-mass displacers was examined on three different stationary phase materials. Several homologous series of displacer molecules were evaluated on these ion- exchange resins using a displacer ranking plot based on the steric mass action model. The results demonstrate that while aromaticity and hydrophobicity can play a significant role in the affinity of displacer molecules on polymethacrylate based and hydrophilized polystyrene–divinylbenzene based materials, this effect is much less pronounced on an agarose based resin. The work presented in this paper demonstrates that different structural features of low-molecular-mass displacers can dominate their affinity on various stationary phase materials employed and provides rules of thumb for the design of high affinity, low-molecular-mass displacers for a variety of commercial cation-exchange materials.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9914657</pmid><doi>10.1016/S0021-9673(98)00805-X</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9673 |
| ispartof | Journal of Chromatography A, 1998-12, Vol.827 (2), p.295-310 |
| issn | 0021-9673 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69139810 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amines Analytical biochemistry: general aspects, technics, instrumentation Analytical chemistry Analytical, structural and metabolic biochemistry Biological and medical sciences Biotechnology Cation Exchange Resins Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Ion Exchange - methods Exact sciences and technology Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Methods. Procedures. Technologies Molecular Structure Other chromatographic methods Others Spectrophotometry, Ultraviolet Various methods and equipments |
| title | Structural characteristics of low-molecular-mass displacers for cation-exchange chromatography: II. Role of the stationary phase |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T00%3A18%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structural%20characteristics%20of%20low-molecular-mass%20displacers%20for%20cation-exchange%20chromatography:%20II.%20Role%20of%20the%20stationary%20phase&rft.jtitle=Journal%20of%20Chromatography%20A&rft.au=Shukla,%20Abhinav%20A.&rft.date=1998-12-11&rft.volume=827&rft.issue=2&rft.spage=295&rft.epage=310&rft.pages=295-310&rft.issn=0021-9673&rft.coden=JOCRAM&rft_id=info:doi/10.1016/S0021-9673(98)00805-X&rft_dat=%3Cproquest_pubme%3E69139810%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69139810&rft_id=info:pmid/9914657&rft_els_id=S002196739800805X&rfr_iscdi=true |