Effectiveness of Bacillus Calmette Guerin (BCG) vaccination in the prevention of childhood pulmonary tuberculosis : A case control study in Nagpur, India
A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in the prevention of childhood pulmonary tuberculosis. The study included 126 incident cases of pulmonary tuberculosis (diagnosed by WHO criteria) below/equal the age of 12 years. Each...
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| Veröffentlicht in: | Southeast Asian journal of tropical medicine and public health 1998-06, Vol.29 (2), p.285-288 |
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| container_title | Southeast Asian journal of tropical medicine and public health |
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| creator | ZODPEY, S. P SHRIKHANDE, S. N MALDHURE, B. R VASUDEO, N. D KULKARNI, S. W |
| description | A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in the prevention of childhood pulmonary tuberculosis. The study included 126 incident cases of pulmonary tuberculosis (diagnosed by WHO criteria) below/equal the age of 12 years. Each case was pair matched with one control for age, sex, socio-economic status. Controls were selected from subjects attending study hospital for conditions other than tuberculosis and leprosy. The significant protective association between BCG and childhood pulmonary tuberculosis was observed (OR = 0.39, 95% CI = 0.22, 0.68). The overall vaccine effectiveness was 61% (95% CI = 32%, 78%). BCG was nonsignificantly more effective in underfives, among males and in upper-middle socioeconomic strata. The overall prevented fraction was estimated to be 47.53% (95% CI = 21.41%, 67.25%). Results of this study thus demonstrated a moderate effectiveness of BCG vaccination in prevention of childhood pulmonary tuberculosis in a Central India population. |
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P ; SHRIKHANDE, S. N ; MALDHURE, B. R ; VASUDEO, N. D ; KULKARNI, S. W</creator><creatorcontrib>ZODPEY, S. P ; SHRIKHANDE, S. N ; MALDHURE, B. R ; VASUDEO, N. D ; KULKARNI, S. W</creatorcontrib><description>A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in the prevention of childhood pulmonary tuberculosis. The study included 126 incident cases of pulmonary tuberculosis (diagnosed by WHO criteria) below/equal the age of 12 years. Each case was pair matched with one control for age, sex, socio-economic status. Controls were selected from subjects attending study hospital for conditions other than tuberculosis and leprosy. The significant protective association between BCG and childhood pulmonary tuberculosis was observed (OR = 0.39, 95% CI = 0.22, 0.68). The overall vaccine effectiveness was 61% (95% CI = 32%, 78%). BCG was nonsignificantly more effective in underfives, among males and in upper-middle socioeconomic strata. The overall prevented fraction was estimated to be 47.53% (95% CI = 21.41%, 67.25%). Results of this study thus demonstrated a moderate effectiveness of BCG vaccination in prevention of childhood pulmonary tuberculosis in a Central India population.</description><identifier>ISSN: 0125-1562</identifier><identifier>PMID: 9886114</identifier><identifier>CODEN: SJTMAK</identifier><language>eng</language><publisher>Bangkok: Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</publisher><subject>Age Factors ; Bacterial diseases ; BCG Vaccine ; Biological and medical sciences ; Case-Control Studies ; Child ; Child, Preschool ; Confidence Intervals ; Female ; Human bacterial diseases ; Humans ; India - epidemiology ; Infant ; Infectious diseases ; Male ; Medical sciences ; Odds Ratio ; Prevalence ; Sex Factors ; Socioeconomic Factors ; Tropical medicine ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - prevention & control</subject><ispartof>Southeast Asian journal of tropical medicine and public health, 1998-06, Vol.29 (2), p.285-288</ispartof><rights>1999 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1622708$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9886114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZODPEY, S. P</creatorcontrib><creatorcontrib>SHRIKHANDE, S. N</creatorcontrib><creatorcontrib>MALDHURE, B. R</creatorcontrib><creatorcontrib>VASUDEO, N. D</creatorcontrib><creatorcontrib>KULKARNI, S. W</creatorcontrib><title>Effectiveness of Bacillus Calmette Guerin (BCG) vaccination in the prevention of childhood pulmonary tuberculosis : A case control study in Nagpur, India</title><title>Southeast Asian journal of tropical medicine and public health</title><addtitle>Southeast Asian J Trop Med Public Health</addtitle><description>A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in the prevention of childhood pulmonary tuberculosis. The study included 126 incident cases of pulmonary tuberculosis (diagnosed by WHO criteria) below/equal the age of 12 years. Each case was pair matched with one control for age, sex, socio-economic status. Controls were selected from subjects attending study hospital for conditions other than tuberculosis and leprosy. The significant protective association between BCG and childhood pulmonary tuberculosis was observed (OR = 0.39, 95% CI = 0.22, 0.68). The overall vaccine effectiveness was 61% (95% CI = 32%, 78%). BCG was nonsignificantly more effective in underfives, among males and in upper-middle socioeconomic strata. The overall prevented fraction was estimated to be 47.53% (95% CI = 21.41%, 67.25%). Results of this study thus demonstrated a moderate effectiveness of BCG vaccination in prevention of childhood pulmonary tuberculosis in a Central India population.</description><subject>Age Factors</subject><subject>Bacterial diseases</subject><subject>BCG Vaccine</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Prevalence</subject><subject>Sex Factors</subject><subject>Socioeconomic Factors</subject><subject>Tropical medicine</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><subject>Tuberculosis, Pulmonary - prevention & control</subject><issn>0125-1562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1KAzEUhWeh1Fp9BCELEQULSaaZZty1Q62FohtdlzS5sZFMMuan0EfxbR21uLpwzncO3HNSDDGhbExYRc-K8xg_MJ5gUvNBMag5rwiZDIuvhdYgk9mDgxiR12gupLE2R9QI20JKgJYZgnHodt4s79BeSGmcSMY71ItpB6gL0Md_lT4vd8aqnfcKddm23olwQClvIchsfTQRPaAZkiICkt6l4C2KKavDT9mzeO9yuEcrp4y4KE61sBEuj3dUvD0uXpun8fpluWpm63FHGE7jmnHOCCXbmm0Bal5XU6aJYlpWtOKMwZRijimoCkitS0pLEEqSCVaCak6m5ai4-evtgv_MENOmNVGCtcKBz3FT1aRk5YT34NURzNsW1KYLpu2f2xy37P3roy-iFFYH4aSJ_xipKJ1iXn4DNOl9Eg</recordid><startdate>199806</startdate><enddate>199806</enddate><creator>ZODPEY, S. 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P</creatorcontrib><creatorcontrib>SHRIKHANDE, S. N</creatorcontrib><creatorcontrib>MALDHURE, B. R</creatorcontrib><creatorcontrib>VASUDEO, N. D</creatorcontrib><creatorcontrib>KULKARNI, S. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZODPEY, S. P</au><au>SHRIKHANDE, S. N</au><au>MALDHURE, B. R</au><au>VASUDEO, N. D</au><au>KULKARNI, S. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of Bacillus Calmette Guerin (BCG) vaccination in the prevention of childhood pulmonary tuberculosis : A case control study in Nagpur, India</atitle><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle><addtitle>Southeast Asian J Trop Med Public Health</addtitle><date>1998-06</date><risdate>1998</risdate><volume>29</volume><issue>2</issue><spage>285</spage><epage>288</epage><pages>285-288</pages><issn>0125-1562</issn><coden>SJTMAK</coden><abstract>A hospital-based, pair matched, case control study was carried out to estimate the effectiveness of BCG vaccination in the prevention of childhood pulmonary tuberculosis. The study included 126 incident cases of pulmonary tuberculosis (diagnosed by WHO criteria) below/equal the age of 12 years. Each case was pair matched with one control for age, sex, socio-economic status. Controls were selected from subjects attending study hospital for conditions other than tuberculosis and leprosy. The significant protective association between BCG and childhood pulmonary tuberculosis was observed (OR = 0.39, 95% CI = 0.22, 0.68). The overall vaccine effectiveness was 61% (95% CI = 32%, 78%). BCG was nonsignificantly more effective in underfives, among males and in upper-middle socioeconomic strata. The overall prevented fraction was estimated to be 47.53% (95% CI = 21.41%, 67.25%). Results of this study thus demonstrated a moderate effectiveness of BCG vaccination in prevention of childhood pulmonary tuberculosis in a Central India population.</abstract><cop>Bangkok</cop><pub>Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</pub><pmid>9886114</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Southeast Asian journal of tropical medicine and public health, 1998-06, Vol.29 (2), p.285-288 |
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| subjects | Age Factors Bacterial diseases BCG Vaccine Biological and medical sciences Case-Control Studies Child Child, Preschool Confidence Intervals Female Human bacterial diseases Humans India - epidemiology Infant Infectious diseases Male Medical sciences Odds Ratio Prevalence Sex Factors Socioeconomic Factors Tropical medicine Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - prevention & control |
| title | Effectiveness of Bacillus Calmette Guerin (BCG) vaccination in the prevention of childhood pulmonary tuberculosis : A case control study in Nagpur, India |
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