Treatment of Opisthorchis viverrini and intestinal fluke infections with praziquantel
The study was carried out from September to November 1997 in Phrae Province of northern Thailand. A total of 95 adult patients with Opisthorchis-like ova in their stools were randomly treated with two different manufactured Praziquantels. Group 1, consisting of 49 patients, received a single dose of...
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| Veröffentlicht in: | Southeast Asian journal of tropical medicine and public health 1998-06, Vol.29 (2), p.246-249 |
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| container_title | Southeast Asian journal of tropical medicine and public health |
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| creator | PUNGPAK, S RADOMYOS, P RADOMYOS, B.-E SCHELP, F. P JONGSUKSUNTIGUL, P BUNNAG, D |
| description | The study was carried out from September to November 1997 in Phrae Province of northern Thailand. A total of 95 adult patients with Opisthorchis-like ova in their stools were randomly treated with two different manufactured Praziquantels. Group 1, consisting of 49 patients, received a single dose of 40 mg per kg Praziquantel manufactured by the Thai Government Pharmaceutical Organization. Group 2 (46 patients) received Biltricide at the same dosage. Haplorchis taichui, H. yokogawai, Echinostome spp., O. viverrini, Taenia saginata and Enterobius vermicularis were expelled in the stools after treatment. Minute intestinal flukes were detected in 64% of patients. O. viverrini was found in lower proportion of 17%. By formalin-ether concentration examination one stool specimen from each patient, the cure rate in both groups on the 30th day of treatment was 100%. The side effects of the two different Praziquantel treatments were mild with no significant difference. Praziquantel, regardless of its manufacture, proved effective against O. viverrini and other minute intestinal flukes (H. taichui, H. yokogawai and Echinostome spp). |
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P ; JONGSUKSUNTIGUL, P ; BUNNAG, D</creator><creatorcontrib>PUNGPAK, S ; RADOMYOS, P ; RADOMYOS, B.-E ; SCHELP, F. P ; JONGSUKSUNTIGUL, P ; BUNNAG, D</creatorcontrib><description>The study was carried out from September to November 1997 in Phrae Province of northern Thailand. A total of 95 adult patients with Opisthorchis-like ova in their stools were randomly treated with two different manufactured Praziquantels. Group 1, consisting of 49 patients, received a single dose of 40 mg per kg Praziquantel manufactured by the Thai Government Pharmaceutical Organization. Group 2 (46 patients) received Biltricide at the same dosage. Haplorchis taichui, H. yokogawai, Echinostome spp., O. viverrini, Taenia saginata and Enterobius vermicularis were expelled in the stools after treatment. Minute intestinal flukes were detected in 64% of patients. O. viverrini was found in lower proportion of 17%. By formalin-ether concentration examination one stool specimen from each patient, the cure rate in both groups on the 30th day of treatment was 100%. The side effects of the two different Praziquantel treatments were mild with no significant difference. Praziquantel, regardless of its manufacture, proved effective against O. viverrini and other minute intestinal flukes (H. taichui, H. yokogawai and Echinostome spp).</description><identifier>ISSN: 0125-1562</identifier><identifier>PMID: 9886106</identifier><identifier>CODEN: SJTMAK</identifier><language>eng</language><publisher>Bangkok: Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</publisher><subject>Adolescent ; Adult ; Aged ; Animals ; Antibiotics. Antiinfectious agents. 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P</creatorcontrib><creatorcontrib>JONGSUKSUNTIGUL, P</creatorcontrib><creatorcontrib>BUNNAG, D</creatorcontrib><title>Treatment of Opisthorchis viverrini and intestinal fluke infections with praziquantel</title><title>Southeast Asian journal of tropical medicine and public health</title><addtitle>Southeast Asian J Trop Med Public Health</addtitle><description>The study was carried out from September to November 1997 in Phrae Province of northern Thailand. A total of 95 adult patients with Opisthorchis-like ova in their stools were randomly treated with two different manufactured Praziquantels. Group 1, consisting of 49 patients, received a single dose of 40 mg per kg Praziquantel manufactured by the Thai Government Pharmaceutical Organization. Group 2 (46 patients) received Biltricide at the same dosage. Haplorchis taichui, H. yokogawai, Echinostome spp., O. viverrini, Taenia saginata and Enterobius vermicularis were expelled in the stools after treatment. Minute intestinal flukes were detected in 64% of patients. O. viverrini was found in lower proportion of 17%. By formalin-ether concentration examination one stool specimen from each patient, the cure rate in both groups on the 30th day of treatment was 100%. The side effects of the two different Praziquantel treatments were mild with no significant difference. Praziquantel, regardless of its manufacture, proved effective against O. viverrini and other minute intestinal flukes (H. taichui, H. yokogawai and Echinostome spp).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Antiplatyhelmintic Agents - pharmacology</subject><subject>Antiplatyhelmintic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Diseases, Parasitic - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Opisthorchiasis - drug therapy</subject><subject>Opisthorchis - isolation & purification</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Antiplatyhelmintic Agents - pharmacology</topic><topic>Antiplatyhelmintic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Diseases, Parasitic - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Opisthorchiasis - drug therapy</topic><topic>Opisthorchis - isolation & purification</topic><topic>Pharmacology. Drug treatments</topic><topic>Praziquantel - pharmacology</topic><topic>Praziquantel - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Tropical medicine</topic><toplevel>online_resources</toplevel><creatorcontrib>PUNGPAK, S</creatorcontrib><creatorcontrib>RADOMYOS, P</creatorcontrib><creatorcontrib>RADOMYOS, B.-E</creatorcontrib><creatorcontrib>SCHELP, F. P</creatorcontrib><creatorcontrib>JONGSUKSUNTIGUL, P</creatorcontrib><creatorcontrib>BUNNAG, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PUNGPAK, S</au><au>RADOMYOS, P</au><au>RADOMYOS, B.-E</au><au>SCHELP, F. P</au><au>JONGSUKSUNTIGUL, P</au><au>BUNNAG, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Opisthorchis viverrini and intestinal fluke infections with praziquantel</atitle><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle><addtitle>Southeast Asian J Trop Med Public Health</addtitle><date>1998-06</date><risdate>1998</risdate><volume>29</volume><issue>2</issue><spage>246</spage><epage>249</epage><pages>246-249</pages><issn>0125-1562</issn><coden>SJTMAK</coden><abstract>The study was carried out from September to November 1997 in Phrae Province of northern Thailand. A total of 95 adult patients with Opisthorchis-like ova in their stools were randomly treated with two different manufactured Praziquantels. Group 1, consisting of 49 patients, received a single dose of 40 mg per kg Praziquantel manufactured by the Thai Government Pharmaceutical Organization. Group 2 (46 patients) received Biltricide at the same dosage. Haplorchis taichui, H. yokogawai, Echinostome spp., O. viverrini, Taenia saginata and Enterobius vermicularis were expelled in the stools after treatment. Minute intestinal flukes were detected in 64% of patients. O. viverrini was found in lower proportion of 17%. By formalin-ether concentration examination one stool specimen from each patient, the cure rate in both groups on the 30th day of treatment was 100%. The side effects of the two different Praziquantel treatments were mild with no significant difference. Praziquantel, regardless of its manufacture, proved effective against O. viverrini and other minute intestinal flukes (H. taichui, H. yokogawai and Echinostome spp).</abstract><cop>Bangkok</cop><pub>Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</pub><pmid>9886106</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Southeast Asian journal of tropical medicine and public health, 1998-06, Vol.29 (2), p.246-249 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiplatyhelmintic Agents - pharmacology Antiplatyhelmintic Agents - therapeutic use Biological and medical sciences Female Humans Intestinal Diseases, Parasitic - drug therapy Male Medical sciences Middle Aged Opisthorchiasis - drug therapy Opisthorchis - isolation & purification Pharmacology. Drug treatments Praziquantel - pharmacology Praziquantel - therapeutic use Treatment Outcome Tropical medicine |
| title | Treatment of Opisthorchis viverrini and intestinal fluke infections with praziquantel |
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