Chemical approaches to mapping the function of post-translational modifications

Strategies for the chemical construction of synthetic proteins with precisely positioned post-translational modifications or their mimics offer a powerful method for dissecting the complexity of functional protein alteration and the associated complexity of proteomes.

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Bibliographische Detailangaben
Veröffentlicht in:	The FEBS journal 2008-05, Vol.275 (9), p.1949-1959
Hauptverfasser:	Gamblin, David P, van Kasteren, Sander I, Chalker, Justin M, Davis, Benjamin G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biotechnology chemoselective ligation Forecasting Glycoproteins - biosynthesis Glycosylation Humans Models, Molecular Molecular Mimicry post‐translational modification protein glycosylation Protein Interaction Mapping protein modification Protein Processing, Post-Translational Protein synthesis Proteomics synthetic proteins
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Beschreibung
Zusammenfassung:	Strategies for the chemical construction of synthetic proteins with precisely positioned post-translational modifications or their mimics offer a powerful method for dissecting the complexity of functional protein alteration and the associated complexity of proteomes.
ISSN:	1742-464X 1742-4658
DOI:	10.1111/j.1742-4658.2008.06347.x