The effect of mitomycin-C on the biodistribution of 99Tcm-MDP in Balb/c mice
SUMMARYDrug therapy can alter the biodistribuition of radiopharmaceuticals. We studied the effect of mitomycin-C, a drug used in oncology, on the biodistribution in mice of Tc-methylene diphosphonic acid (Tc-MDP). Three doses of mitomycin-C were administered. After the last dose, Tc-MDP was injected...
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| Veröffentlicht in: | Nuclear medicine communications 1998-12, Vol.19 (12), p.1177-1180 |
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| container_title | Nuclear medicine communications |
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| creator | GOMES, M L DE SOUZA BRAGA, A C DE MATTOS, D M.M SOUZA FREITAS, R DE BOASQUEVISQUE, E M BERNARDOFILHO, M |
| description | SUMMARYDrug therapy can alter the biodistribuition of radiopharmaceuticals. We studied the effect of mitomycin-C, a drug used in oncology, on the biodistribution in mice of Tc-methylene diphosphonic acid (Tc-MDP). Three doses of mitomycin-C were administered. After the last dose, Tc-MDP was injected and the animals were killed. The organs were isolated, their weight determined and the percent per gram injected dose (%ID/g) calculated. The %ID/g had increased in the pancreas, ovary, stomach, uterus, kidneys, spleen, thymus, heart, liver and lungs, but did not change significantly in thyroid, bone or brain. As a change in Tc-MDP uptake by bone is not observed, a modification to bone scintigraphy is not required. As mitomycin-C treatment altered Tc-MDP uptake in some organs, any hot spots should be evaluated carefully to avoid a misdiagnosis. |
| doi_str_mv | 10.1097/00006231-199812000-00010 |
| format | Article |
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We studied the effect of mitomycin-C, a drug used in oncology, on the biodistribution in mice of Tc-methylene diphosphonic acid (Tc-MDP). Three doses of mitomycin-C were administered. After the last dose, Tc-MDP was injected and the animals were killed. The organs were isolated, their weight determined and the percent per gram injected dose (%ID/g) calculated. The %ID/g had increased in the pancreas, ovary, stomach, uterus, kidneys, spleen, thymus, heart, liver and lungs, but did not change significantly in thyroid, bone or brain. As a change in Tc-MDP uptake by bone is not observed, a modification to bone scintigraphy is not required. As mitomycin-C treatment altered Tc-MDP uptake in some organs, any hot spots should be evaluated carefully to avoid a misdiagnosis.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/00006231-199812000-00010</identifier><identifier>PMID: 9885808</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Biological and medical sciences ; Contrast media. Radiopharmaceuticals ; Dose-Response Relationship, Drug ; Female ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mitomycin - pharmacology ; Pharmacology. Drug treatments ; Radiopharmaceuticals - pharmacokinetics ; Technetium Tc 99m Medronate - pharmacokinetics ; Tissue Distribution - drug effects</subject><ispartof>Nuclear medicine communications, 1998-12, Vol.19 (12), p.1177-1180</ispartof><rights>1998 Lippincott Williams & Wilkins, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2310-37a298ae3074511aafd8b83e20a8502906154d465e7789e6fe3b5da4a08696b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1636097$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9885808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOMES, M L</creatorcontrib><creatorcontrib>DE SOUZA BRAGA, A C</creatorcontrib><creatorcontrib>DE MATTOS, D M.M</creatorcontrib><creatorcontrib>SOUZA FREITAS, R DE</creatorcontrib><creatorcontrib>BOASQUEVISQUE, E M</creatorcontrib><creatorcontrib>BERNARDOFILHO, M</creatorcontrib><title>The effect of mitomycin-C on the biodistribution of 99Tcm-MDP in Balb/c mice</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>SUMMARYDrug therapy can alter the biodistribuition of radiopharmaceuticals. We studied the effect of mitomycin-C, a drug used in oncology, on the biodistribution in mice of Tc-methylene diphosphonic acid (Tc-MDP). Three doses of mitomycin-C were administered. After the last dose, Tc-MDP was injected and the animals were killed. The organs were isolated, their weight determined and the percent per gram injected dose (%ID/g) calculated. The %ID/g had increased in the pancreas, ovary, stomach, uterus, kidneys, spleen, thymus, heart, liver and lungs, but did not change significantly in thyroid, bone or brain. As a change in Tc-MDP uptake by bone is not observed, a modification to bone scintigraphy is not required. As mitomycin-C treatment altered Tc-MDP uptake in some organs, any hot spots should be evaluated carefully to avoid a misdiagnosis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mitomycin - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Technetium Tc 99m Medronate - pharmacokinetics</subject><subject>Tissue Distribution - drug effects</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PwyAYx4nRzDn9CCY9GG84KIXCUedrMqOHeSaUPs3Qvkxos-zbi27OkySEwP8F8gOhhJIrSlQ-JXGIlFFMlZI0jTscJyUHaEyznGEuUnmIxoRmDDPBxDE6CeE9WiQT-QiNlJRcEjlG88USEqgqsH3SVUnj-q7ZWNfiWdK1SR_FwnWlC713xdC7eBZdSi1sg59vXxPXJjemLqY2Ji2coqPK1AHOdusEvd3fLWaPeP7y8DS7nmMbn0wwy02qpAFG8oxTakxVykIySImRnKSKCMqzMhMc8lwqEBWwgpcmM0QKJQrOJuhy27vy3ecAodeNCxbq2rTQDUELRRnjUkWj3Bqt70LwUOmVd43xG02J_gapf0HqPUj9AzJGz3d3DEUD5T64Ixf1i51ugjV15U1rXfjrj9Bjf7RlW9u6q3vw4aMe1uD1EkzdL_V_38i-AFKWhyA</recordid><startdate>199812</startdate><enddate>199812</enddate><creator>GOMES, M L</creator><creator>DE SOUZA BRAGA, A C</creator><creator>DE MATTOS, D M.M</creator><creator>SOUZA FREITAS, R DE</creator><creator>BOASQUEVISQUE, E M</creator><creator>BERNARDOFILHO, M</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199812</creationdate><title>The effect of mitomycin-C on the biodistribution of 99Tcm-MDP in Balb/c mice</title><author>GOMES, M L ; DE SOUZA BRAGA, A C ; DE MATTOS, D M.M ; SOUZA FREITAS, R DE ; BOASQUEVISQUE, E M ; BERNARDOFILHO, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2310-37a298ae3074511aafd8b83e20a8502906154d465e7789e6fe3b5da4a08696b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mitomycin - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Technetium Tc 99m Medronate - pharmacokinetics</topic><topic>Tissue Distribution - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOMES, M L</creatorcontrib><creatorcontrib>DE SOUZA BRAGA, A C</creatorcontrib><creatorcontrib>DE MATTOS, D M.M</creatorcontrib><creatorcontrib>SOUZA FREITAS, R DE</creatorcontrib><creatorcontrib>BOASQUEVISQUE, E M</creatorcontrib><creatorcontrib>BERNARDOFILHO, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOMES, M L</au><au>DE SOUZA BRAGA, A C</au><au>DE MATTOS, D M.M</au><au>SOUZA FREITAS, R DE</au><au>BOASQUEVISQUE, E M</au><au>BERNARDOFILHO, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of mitomycin-C on the biodistribution of 99Tcm-MDP in Balb/c mice</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>1998-12</date><risdate>1998</risdate><volume>19</volume><issue>12</issue><spage>1177</spage><epage>1180</epage><pages>1177-1180</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>SUMMARYDrug therapy can alter the biodistribuition of radiopharmaceuticals. We studied the effect of mitomycin-C, a drug used in oncology, on the biodistribution in mice of Tc-methylene diphosphonic acid (Tc-MDP). Three doses of mitomycin-C were administered. After the last dose, Tc-MDP was injected and the animals were killed. The organs were isolated, their weight determined and the percent per gram injected dose (%ID/g) calculated. The %ID/g had increased in the pancreas, ovary, stomach, uterus, kidneys, spleen, thymus, heart, liver and lungs, but did not change significantly in thyroid, bone or brain. As a change in Tc-MDP uptake by bone is not observed, a modification to bone scintigraphy is not required. As mitomycin-C treatment altered Tc-MDP uptake in some organs, any hot spots should be evaluated carefully to avoid a misdiagnosis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>9885808</pmid><doi>10.1097/00006231-199812000-00010</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0143-3636 |
| ispartof | Nuclear medicine communications, 1998-12, Vol.19 (12), p.1177-1180 |
| issn | 0143-3636 1473-5628 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Contrast media. Radiopharmaceuticals Dose-Response Relationship, Drug Female Medical sciences Mice Mice, Inbred BALB C Mitomycin - pharmacology Pharmacology. Drug treatments Radiopharmaceuticals - pharmacokinetics Technetium Tc 99m Medronate - pharmacokinetics Tissue Distribution - drug effects |
| title | The effect of mitomycin-C on the biodistribution of 99Tcm-MDP in Balb/c mice |
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