Differentiated Thyroid Carcinoma in a Juvenile Patient
Juvenile differentiated carcinoma thyroid is a rare entity. It differs from adult differentiated thyroid carcinoma in a variety of ways, including large tumor volume at presentation with early involvement of the capsule, more frequent nodal and distant metastases, greater expression of sodium-iodide...
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| Veröffentlicht in: | Clinical nuclear medicine 2008-05, Vol.33 (5), p.319-320 |
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| container_title | Clinical nuclear medicine |
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| creator | Khan, Muhammad Umar Nawaz, Mohammad Khalid Saadullah, Muhammad Syed, Aamir Ali Hussain, Raza Azhar, Rafay Shah, Mazhar Ali |
| description | Juvenile differentiated carcinoma thyroid is a rare entity. It differs from adult differentiated thyroid carcinoma in a variety of ways, including large tumor volume at presentation with early involvement of the capsule, more frequent nodal and distant metastases, greater expression of sodium-iodide symporter and early recurrence. The overall survival seems to be better than for adult patients; however, due to high and early recurrence rates, prompt and adequate treatment is advocated. The mainstay of treatment includes total thyroidectomy, central lymphadenectomy with modified radical lateral lymphadenectomy, followed by ablation with radioactive iodine (RAI). Both modalities improve the final outcome, but RAI ablation decreases cause-specific death risk independent of the extent of surgery. We present the case of a 5-year-old girl, the youngest ever treated in our country with surgery and RAI therapy successfully after being diagnosed as papillary carcinoma of the thyroid, follicular variant. |
| doi_str_mv | 10.1097/RLU.0b013e31816a7944 |
| format | Article |
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It differs from adult differentiated thyroid carcinoma in a variety of ways, including large tumor volume at presentation with early involvement of the capsule, more frequent nodal and distant metastases, greater expression of sodium-iodide symporter and early recurrence. The overall survival seems to be better than for adult patients; however, due to high and early recurrence rates, prompt and adequate treatment is advocated. The mainstay of treatment includes total thyroidectomy, central lymphadenectomy with modified radical lateral lymphadenectomy, followed by ablation with radioactive iodine (RAI). Both modalities improve the final outcome, but RAI ablation decreases cause-specific death risk independent of the extent of surgery. 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It differs from adult differentiated thyroid carcinoma in a variety of ways, including large tumor volume at presentation with early involvement of the capsule, more frequent nodal and distant metastases, greater expression of sodium-iodide symporter and early recurrence. The overall survival seems to be better than for adult patients; however, due to high and early recurrence rates, prompt and adequate treatment is advocated. The mainstay of treatment includes total thyroidectomy, central lymphadenectomy with modified radical lateral lymphadenectomy, followed by ablation with radioactive iodine (RAI). Both modalities improve the final outcome, but RAI ablation decreases cause-specific death risk independent of the extent of surgery. We present the case of a 5-year-old girl, the youngest ever treated in our country with surgery and RAI therapy successfully after being diagnosed as papillary carcinoma of the thyroid, follicular variant.</description><subject>Adenocarcinoma, Follicular - diagnosis</subject><subject>Adenocarcinoma, Follicular - radiotherapy</subject><subject>Adenocarcinoma, Follicular - surgery</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Radiopharmaceuticals - therapeutic use</subject><subject>Radiotherapy, Adjuvant</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - radiotherapy</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Treatment Outcome</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMFu1DAQhi0EotuWN0AoJ24pMx7HiY9ogbZoJVDVni3bGWsN2aTYCVXfnlRdqRJzGc3o_7_DJ8R7hAsE03662d1dgAckJuxQu9Yo9UpssCFdg5TmtdgAaapNq-WJOC3lFwBq1OqtOMFOEaKSG6G_pBg58zgnN3Nf3e4f85T6autySON0cFUaK1d9X_7ymAaufro5reFz8Sa6ofC74z4Td9--3m6v6t2Py-vt510dqAGsg3RextZ53QaMPXo0oMgbln2M1JiOuxijDB5MINUC9bLxMriGI0XlOzoTH5-593n6s3CZ7SGVwMPgRp6WYrVBkoRmDarnYMhTKZmjvc_p4PKjRbBPvuzqy_7va619OPIXf-D-pXQU9MJ9mIaZc_k9LA-c7Z7dMO8trEPQyloCdNCsV_30QvoHBIx2Zg</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Khan, Muhammad Umar</creator><creator>Nawaz, Mohammad Khalid</creator><creator>Saadullah, Muhammad</creator><creator>Syed, Aamir Ali</creator><creator>Hussain, Raza</creator><creator>Azhar, Rafay</creator><creator>Shah, Mazhar Ali</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>Differentiated Thyroid Carcinoma in a Juvenile Patient</title><author>Khan, Muhammad Umar ; Nawaz, Mohammad Khalid ; Saadullah, Muhammad ; Syed, Aamir Ali ; Hussain, Raza ; Azhar, Rafay ; Shah, Mazhar Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3501-c2ab2f7ab67c1fd1b19043b9e2dff3598e8fff2cb09c34703d25b2ca5ef3f4b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma, Follicular - diagnosis</topic><topic>Adenocarcinoma, Follicular - radiotherapy</topic><topic>Adenocarcinoma, Follicular - surgery</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Radiopharmaceuticals - therapeutic use</topic><topic>Radiotherapy, Adjuvant</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - radiotherapy</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Muhammad Umar</creatorcontrib><creatorcontrib>Nawaz, Mohammad Khalid</creatorcontrib><creatorcontrib>Saadullah, Muhammad</creatorcontrib><creatorcontrib>Syed, Aamir Ali</creatorcontrib><creatorcontrib>Hussain, Raza</creatorcontrib><creatorcontrib>Azhar, Rafay</creatorcontrib><creatorcontrib>Shah, Mazhar Ali</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Muhammad Umar</au><au>Nawaz, Mohammad Khalid</au><au>Saadullah, Muhammad</au><au>Syed, Aamir Ali</au><au>Hussain, Raza</au><au>Azhar, Rafay</au><au>Shah, Mazhar Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiated Thyroid Carcinoma in a Juvenile Patient</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>2008-05</date><risdate>2008</risdate><volume>33</volume><issue>5</issue><spage>319</spage><epage>320</epage><pages>319-320</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><abstract>Juvenile differentiated carcinoma thyroid is a rare entity. 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We present the case of a 5-year-old girl, the youngest ever treated in our country with surgery and RAI therapy successfully after being diagnosed as papillary carcinoma of the thyroid, follicular variant.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18431142</pmid><doi>10.1097/RLU.0b013e31816a7944</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-9762 |
| ispartof | Clinical nuclear medicine, 2008-05, Vol.33 (5), p.319-320 |
| issn | 0363-9762 1536-0229 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenocarcinoma, Follicular - diagnosis Adenocarcinoma, Follicular - radiotherapy Adenocarcinoma, Follicular - surgery Child, Preschool Female Humans Iodine Radioisotopes - therapeutic use Radiopharmaceuticals - therapeutic use Radiotherapy, Adjuvant Thyroid Neoplasms - diagnosis Thyroid Neoplasms - radiotherapy Thyroid Neoplasms - surgery Treatment Outcome |
| title | Differentiated Thyroid Carcinoma in a Juvenile Patient |
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