The effect of epitope variation on the profile of cytotoxic T lymphocyte responses to the HIV envelope glycoprotein

To address the relationship between viral and host factors during HIV infection, we analyzed the effect of viral mutations on T cell responses in seropositive, asymptomatic HLA-A2+ individuals using four envelope (env)-specific peptides with the HLA-A*0201 binding motif. We showed that the natural s...

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Veröffentlicht in:	International immunology 1998-12, Vol.10 (12), p.1789-1799
Hauptverfasser:	Kmieciak, D, Bednarek, I, Takiguchi, M, Wasik, T J, Bratosiewicz, J, Wierzbicki, A, Teppler, H, Pientka, J, Hsu, S H, Kaneko, Y, Kozbor, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV CD28 Antigens - biosynthesis Cell Line Cytotoxicity, Immunologic Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Genetic Variation HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp120 - metabolism HLA-A2 Antigen - metabolism Human immunodeficiency virus Humans Lymphocyte Activation - immunology Prospective Studies Protein Binding - immunology Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism
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