Oral Symptoms Predict Mortality: a Prospective Study in Japan
Several studies have reported positive associations between oral infections and systemic diseases. The purpose of the present study was to evaluate the effects of oral symptoms on mortality from cardiovascular disease (CVD) and pneumonia. Using data from a cohort study in Japan, we analyzed 4,139 in...
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| Veröffentlicht in: | Journal of dental research 2008-05, Vol.87 (5), p.485-489 |
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| container_title | Journal of dental research |
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| creator | Ide, R. Mizoue, T. Fujino, Y. Kubo, T. Pham, T.-M. Shirane, K. Ogimoto, I. Tokui, N. Yoshimura, T. |
| description | Several studies have reported positive associations between oral infections and systemic diseases. The purpose of the present study was to evaluate the effects of oral symptoms on mortality from cardiovascular disease (CVD) and pneumonia. Using data from a cohort study in Japan, we analyzed 4,139 individuals aged 40–79 years. The baseline questionnaire included the following items related to oral symptoms: ‘sensitive teeth’, ‘difficulty in chewing tough food substances’, ‘bleeding gums’, and ‘mouth feels sticky’. We used the Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs) for mortality, after adjustments for lifestyle, socio-economic factors, and history of diseases. Persons complaining that their ‘mouth feels sticky’ had a two-fold higher risk of pneumonia (HR = 2.1; 95%CI, 1.2–3.6), while those complaining of ‘sensitive teeth’ had a lower risk of CVD (HR = 0.4; 95%CI, 0.2–0.9). Some oral symptoms may be predictors of mortality from pneumonia and CVD. |
| doi_str_mv | 10.1177/154405910808700510 |
| format | Article |
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The purpose of the present study was to evaluate the effects of oral symptoms on mortality from cardiovascular disease (CVD) and pneumonia. Using data from a cohort study in Japan, we analyzed 4,139 individuals aged 40–79 years. The baseline questionnaire included the following items related to oral symptoms: ‘sensitive teeth’, ‘difficulty in chewing tough food substances’, ‘bleeding gums’, and ‘mouth feels sticky’. We used the Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs) for mortality, after adjustments for lifestyle, socio-economic factors, and history of diseases. Persons complaining that their ‘mouth feels sticky’ had a two-fold higher risk of pneumonia (HR = 2.1; 95%CI, 1.2–3.6), while those complaining of ‘sensitive teeth’ had a lower risk of CVD (HR = 0.4; 95%CI, 0.2–0.9). Some oral symptoms may be predictors of mortality from pneumonia and CVD.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/154405910808700510</identifier><identifier>PMID: 18434582</identifier><identifier>CODEN: JDREAF</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>Adult ; Aged ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - mortality ; Cohort Studies ; Dentistry ; Female ; Humans ; Male ; Middle Aged ; Mouth Diseases - complications ; Oral Health ; Pneumonia - complications ; Pneumonia - mortality ; Predictive Value of Tests ; Proportional Hazards Models ; Prospective Studies ; Survival Analysis</subject><ispartof>Journal of dental research, 2008-05, Vol.87 (5), p.485-489</ispartof><rights>International and American Associations for Dental Research</rights><rights>Copyright American Association for Dental Research/American Academy of Implant Dentistry May 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-cec4a19be297eb6e9040b8e79fe860a285ab37d8efa9fd109ac815915ea1883c3</citedby><cites>FETCH-LOGICAL-c463t-cec4a19be297eb6e9040b8e79fe860a285ab37d8efa9fd109ac815915ea1883c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/154405910808700510$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/154405910808700510$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18434582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ide, R.</creatorcontrib><creatorcontrib>Mizoue, T.</creatorcontrib><creatorcontrib>Fujino, Y.</creatorcontrib><creatorcontrib>Kubo, T.</creatorcontrib><creatorcontrib>Pham, T.-M.</creatorcontrib><creatorcontrib>Shirane, K.</creatorcontrib><creatorcontrib>Ogimoto, I.</creatorcontrib><creatorcontrib>Tokui, N.</creatorcontrib><creatorcontrib>Yoshimura, T.</creatorcontrib><title>Oral Symptoms Predict Mortality: a Prospective Study in Japan</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>Several studies have reported positive associations between oral infections and systemic diseases. The purpose of the present study was to evaluate the effects of oral symptoms on mortality from cardiovascular disease (CVD) and pneumonia. Using data from a cohort study in Japan, we analyzed 4,139 individuals aged 40–79 years. The baseline questionnaire included the following items related to oral symptoms: ‘sensitive teeth’, ‘difficulty in chewing tough food substances’, ‘bleeding gums’, and ‘mouth feels sticky’. We used the Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs) for mortality, after adjustments for lifestyle, socio-economic factors, and history of diseases. Persons complaining that their ‘mouth feels sticky’ had a two-fold higher risk of pneumonia (HR = 2.1; 95%CI, 1.2–3.6), while those complaining of ‘sensitive teeth’ had a lower risk of CVD (HR = 0.4; 95%CI, 0.2–0.9). 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| ispartof | Journal of dental research, 2008-05, Vol.87 (5), p.485-489 |
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| subjects | Adult Aged Cardiovascular Diseases - complications Cardiovascular Diseases - mortality Cohort Studies Dentistry Female Humans Male Middle Aged Mouth Diseases - complications Oral Health Pneumonia - complications Pneumonia - mortality Predictive Value of Tests Proportional Hazards Models Prospective Studies Survival Analysis |
| title | Oral Symptoms Predict Mortality: a Prospective Study in Japan |
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