Changes in acetylcholine receptor function induce shifts in muscle fiber type composition

AChRε⁻/⁻ mice lack ε-subunits of the acetylcholine receptor and thus fail to express adult-type receptors. The expression of fetal-type receptors throughout postnatal life alters postsynaptic signal transduction and causes a fast-to-slow fiber type transition, both in slow-twitch soleus muscle and i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FEBS journal 2008-05, Vol.275 (9), p.2042-2054
Hauptverfasser:	Jin, Tae-Eun, Wernig, Anton, Witzemann, Veit
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine receptor acetylcholine receptor ε‐subunit knockout mice Animals Biochemistry fast and slow muscle fiber type Gene Expression - physiology Immunohistochemistry Mice Mice, Inbred C57BL Mice, Knockout Motor Endplate - genetics Motor Endplate - metabolism Muscle Contraction - physiology Muscle Fibers, Fast-Twitch - chemistry Muscle Fibers, Fast-Twitch - cytology Muscle Fibers, Fast-Twitch - metabolism Muscle Fibers, Fast-Twitch - physiology Muscle Fibers, Slow-Twitch - chemistry Muscle Fibers, Slow-Twitch - cytology Muscle Fibers, Slow-Twitch - metabolism Muscle Fibers, Slow-Twitch - physiology Muscle, Skeletal - physiology Muscular system Myosin Heavy Chains - analysis Myosin Heavy Chains - genetics Neurotransmitters Protein Isoforms - genetics Protein Isoforms - metabolism real‐time PCR Receptors, Cholinergic - genetics Receptors, Cholinergic - metabolism RNA, Messenger - metabolism Rodents Signal transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!