PPE protein (Rv3425) from DNA segment RD11 of Mycobacterium tuberculosis: a novel immunodominant antigen of Mycobacterium tuberculosis induces humoral and cellular immune responses in mice

ABSTRACT Subtractive DNA hybridization of pathogenic M. bovis and BCG, and comparative genome‐wide DNA microarray analysis of M. tuberculosis H37Rv and BCG identified several RD, designated as RD1 to RD16, between M. tuberculosis and M. bovis on the one hand and BCG on the other. These regions cover...

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Veröffentlicht in:	Microbiology and immunology 2008-04, Vol.52 (4), p.224-230
Hauptverfasser:	Wang, Jiuling, Qie, Yaqing, Zhang, Hongmei, Zhu, Bingdong, Xu, Ying, Liu, Wei, Chen, Jiazhen, Wang, Honghai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Antigens, Bacterial - genetics Antigens, Bacterial - immunology Immunity, Cellular Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology interferon-γ Mice Mice, Inbred C57BL Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Peptide Fragments - immunology PPE family Rv3425 protein Tuberculosis - immunology Tuberculosis Vaccines
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