Adenovirus-mediated In Utero Expression of CFTR Does Not Improve Survival of CFTR Knockout Mice

Gene therapy is being investigated in the treatment of lung-related aspects of the genetic disease, Cystic fibrosis (CF). Clinical studies have demonstrated CF transmembrane conductance regulator (CFTR) expression in the airways of adults with CF using a variety of gene transfer agents. In utero gen...

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Veröffentlicht in:	Molecular therapy 2008-05, Vol.16 (5), p.812-818
Hauptverfasser:	Davies, Lee A, Varathalingam, Anusha, Painter, Hazel, Lawton, Anna E, Sumner-Jones, Stephanie G, Nunez-Alonso, Graciela A, Chan, Mario, Munkonge, Felix, Alton, Eric WFW, Hyde, Stephen C, Gill, Deborah R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Amniotic Fluid - metabolism Animals Cystic fibrosis Cystic Fibrosis - genetics Cystic Fibrosis - therapy Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Female Fetuses Gene expression Gene Expression Regulation Gene therapy Genetic Therapy - methods Genetic Vectors Humans Intestinal obstruction Lungs Mice Mice, Inbred C57BL Mice, Knockout Microscopy Pregnancy Pregnancy, Animal
Online-Zugang:	Volltext
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