Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

The adipocyte-derived hormone leptin decreases body weight in part by activating the sympathetic nervous system, resulting in increased thermogenesis and energy expenditure. We investigated hypothalamic pathways underlying leptin’s effects on stimulating the sympathetic nervous system. We found that...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1998-12, Vol.21 (6), p.1375-1385
Hauptverfasser:	Elias, Carol F., Lee, Charlotte, Kelly, Joseph, Aschkenasi, Carl, Ahima, Rexford S., Couceyro, Pastor R., Kuhar, Michael J., Saper, Clifford B., Elmquist, Joel K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arcuate nucleus Arcuate Nucleus of Hypothalamus - drug effects Arcuate Nucleus of Hypothalamus - physiology Body Temperature Regulation - drug effects Body Weight - drug effects CART protein Energy Metabolism - drug effects Hypothalamus - drug effects Hypothalamus - physiology Leptin Male Microinjections Nerve Tissue Proteins - genetics Neural Pathways - drug effects Neural Pathways - physiology Neurons - drug effects Neurons - physiology Organ Specificity Pro-Opiomelanocortin - genetics Proteins - administration & dosage Proteins - pharmacology Rats Rats, Sprague-Dawley retrochiasmatic area RNA, Messenger - metabolism Spinal Cord - drug effects Spinal Cord - physiology Transcription, Genetic - drug effects
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