Metastatic basal cell carcinoma exhibits reduced actin expression
Basal cell carcinoma is the most common malignancy in Caucasian individuals. Metastatic basal cell carcinoma is extremely rare (with a rate estimated as 0.03%). Actin has been detected in aggressive forms of basal cell carcinoma, but their expression in metastatic lesions is not known. We compared t...
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| Veröffentlicht in: | Modern pathology 2008-05, Vol.21 (5), p.540-543 |
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| creator | Uzquiano, Maria C Prieto, Victor G Nash, Jason W Ivan, Doina S Gong, Yun Lazar, Alexander J F Diwan, A Hafeez |
| description | Basal cell carcinoma is the most common malignancy in Caucasian individuals. Metastatic basal cell carcinoma is extremely rare (with a rate estimated as 0.03%). Actin has been detected in aggressive forms of basal cell carcinoma, but their expression in metastatic lesions is not known. We compared the expression of actin and actin-related cytoskeletal proteins in relatively less aggressive basal cell carcinoma (nodular), aggressive basal cell carcinoma (infiltrative/morpheaform), and metastatic basal cell carcinoma. We studied 12 cases of nodular basal cell carcinoma, 10 cases of infiltrative basal cell carcinoma, and 10 cases of metastatic basal cell carcinoma with immunohistochemistry for alpha-smooth muscle actin, calponin, myosin, and E-cadherin. Expression was interpreted as positive when at least 5% of the tumor exhibited at least weak expression. Five of the ten patients with metastatic basal cell carcinoma had an antecedent history of radiotherapy. Actin was present in 3 of 12 (25%) of the nodular, all 10 of the infiltrative, and 3 of 10 of the metastatic basal cell carcinomas (P |
| doi_str_mv | 10.1038/modpathol.3801051 |
| format | Article |
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Metastatic basal cell carcinoma is extremely rare (with a rate estimated as 0.03%). Actin has been detected in aggressive forms of basal cell carcinoma, but their expression in metastatic lesions is not known. We compared the expression of actin and actin-related cytoskeletal proteins in relatively less aggressive basal cell carcinoma (nodular), aggressive basal cell carcinoma (infiltrative/morpheaform), and metastatic basal cell carcinoma. We studied 12 cases of nodular basal cell carcinoma, 10 cases of infiltrative basal cell carcinoma, and 10 cases of metastatic basal cell carcinoma with immunohistochemistry for alpha-smooth muscle actin, calponin, myosin, and E-cadherin. Expression was interpreted as positive when at least 5% of the tumor exhibited at least weak expression. Five of the ten patients with metastatic basal cell carcinoma had an antecedent history of radiotherapy. Actin was present in 3 of 12 (25%) of the nodular, all 10 of the infiltrative, and 3 of 10 of the metastatic basal cell carcinomas (P<0.05 for metastatic vs infiltrative and nodular vs infiltrative). Calponin was present in 50% of the nodular, 60% of the infiltrative, and 30% of the metastatic basal cell carcinomas (not statistically significant). Myosin expression was not detected in any of the cases. E-cadherin was present in 75% of the nodular, 70% of the infiltrative, and all of the metastatic basal cell carcinomas (P<0.05 for metastatic vs nodular). Our results suggest that increased actin may contribute to local invasiveness, but it is lost in the metastatic phenotype. History of previous radiotherapy may contribute to development of the metastatic phenotype.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.3801051</identifier><identifier>PMID: 18223552</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>actin ; Actins - biosynthesis ; Adult ; Aged ; Aged, 80 and over ; basal cell carcinoma ; Cadherins - biosynthesis ; Calcium-Binding Proteins - biosynthesis ; Calponins ; Cancer ; Carcinoma, Basal Cell - metabolism ; Carcinoma, Basal Cell - pathology ; Female ; Genotype & phenotype ; Humans ; Immunohistochemistry ; Laboratory Medicine ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastasis ; Microfilament Proteins - biosynthesis ; Middle Aged ; Monoclonal antibodies ; Myosins - biosynthesis ; Neoplasm Invasiveness ; original-article ; Pathology ; Radiation therapy ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Smooth muscle ; Tumors ; White people</subject><ispartof>Modern pathology, 2008-05, Vol.21 (5), p.540-543</ispartof><rights>2008 United States & Canadian Academy of Pathology</rights><rights>United States and Canadian Academy of Pathology, Inc. 2008</rights><rights>Copyright Nature Publishing Group May 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-f925eb430bf8843bd9e264ea78b905a08be60fc945c611156e450ce7028530e33</citedby><cites>FETCH-LOGICAL-c464t-f925eb430bf8843bd9e264ea78b905a08be60fc945c611156e450ce7028530e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18223552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uzquiano, Maria C</creatorcontrib><creatorcontrib>Prieto, Victor G</creatorcontrib><creatorcontrib>Nash, Jason W</creatorcontrib><creatorcontrib>Ivan, Doina S</creatorcontrib><creatorcontrib>Gong, Yun</creatorcontrib><creatorcontrib>Lazar, Alexander J F</creatorcontrib><creatorcontrib>Diwan, A Hafeez</creatorcontrib><title>Metastatic basal cell carcinoma exhibits reduced actin expression</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>Basal cell carcinoma is the most common malignancy in Caucasian individuals. Metastatic basal cell carcinoma is extremely rare (with a rate estimated as 0.03%). Actin has been detected in aggressive forms of basal cell carcinoma, but their expression in metastatic lesions is not known. We compared the expression of actin and actin-related cytoskeletal proteins in relatively less aggressive basal cell carcinoma (nodular), aggressive basal cell carcinoma (infiltrative/morpheaform), and metastatic basal cell carcinoma. We studied 12 cases of nodular basal cell carcinoma, 10 cases of infiltrative basal cell carcinoma, and 10 cases of metastatic basal cell carcinoma with immunohistochemistry for alpha-smooth muscle actin, calponin, myosin, and E-cadherin. Expression was interpreted as positive when at least 5% of the tumor exhibited at least weak expression. Five of the ten patients with metastatic basal cell carcinoma had an antecedent history of radiotherapy. Actin was present in 3 of 12 (25%) of the nodular, all 10 of the infiltrative, and 3 of 10 of the metastatic basal cell carcinomas (P<0.05 for metastatic vs infiltrative and nodular vs infiltrative). Calponin was present in 50% of the nodular, 60% of the infiltrative, and 30% of the metastatic basal cell carcinomas (not statistically significant). Myosin expression was not detected in any of the cases. E-cadherin was present in 75% of the nodular, 70% of the infiltrative, and all of the metastatic basal cell carcinomas (P<0.05 for metastatic vs nodular). Our results suggest that increased actin may contribute to local invasiveness, but it is lost in the metastatic phenotype. History of previous radiotherapy may contribute to development of the metastatic phenotype.</description><subject>actin</subject><subject>Actins - biosynthesis</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>basal cell carcinoma</subject><subject>Cadherins - biosynthesis</subject><subject>Calcium-Binding Proteins - biosynthesis</subject><subject>Calponins</subject><subject>Cancer</subject><subject>Carcinoma, Basal Cell - metabolism</subject><subject>Carcinoma, Basal Cell - pathology</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Microfilament Proteins - biosynthesis</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Myosins - biosynthesis</subject><subject>Neoplasm Invasiveness</subject><subject>original-article</subject><subject>Pathology</subject><subject>Radiation therapy</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Smooth muscle</subject><subject>Tumors</subject><subject>White people</subject><issn>0893-3952</issn><issn>1530-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kEtLAzEYRYMotlZ_gBsZXLgbzbsZXBXxBYobXYdM5hsb6UxqkhH996a0WHDRTQLJuTdfDkKnBF8SzNRV55ulSXO_uGQKEyzIHhoTwXCJqRL7aIxVxUpWCTpCRzF-YEy4UPQQjYiilAlBx2j2DMnEZJKzRW2iWRQWFnkxwbred6aA77mrXYpFgGaw0BTGJtfn42WAGJ3vj9FBaxYRTjb7BL3d3b7ePJRPL_ePN7On0nLJU9lWVEDNGa5bpTirmwqo5GCmqq6wMFjVIHFrKy6sJIQICVxgC9PVVxgGxiboYt27DP5zgJh05-JqWNODH6KWFaFKVjKD5__ADz-EPs-mKSVEUjblGSJryAYfY4BWL4PrTPjRBOuVXP0nV2_k5szZpnioO2i2iY3NDNA1EPNV_w5h-_Ku1ut1CLK8L5dD0Tros2oXwCbdeLcj_Qv2UJxK</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Uzquiano, Maria C</creator><creator>Prieto, Victor G</creator><creator>Nash, Jason W</creator><creator>Ivan, Doina S</creator><creator>Gong, Yun</creator><creator>Lazar, Alexander J F</creator><creator>Diwan, A Hafeez</creator><general>Elsevier Inc</general><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080501</creationdate><title>Metastatic basal cell carcinoma exhibits reduced actin expression</title><author>Uzquiano, Maria C ; Prieto, Victor G ; Nash, Jason W ; Ivan, Doina S ; Gong, Yun ; Lazar, Alexander J F ; Diwan, A Hafeez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-f925eb430bf8843bd9e264ea78b905a08be60fc945c611156e450ce7028530e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>actin</topic><topic>Actins - 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Academic</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uzquiano, Maria C</au><au>Prieto, Victor G</au><au>Nash, Jason W</au><au>Ivan, Doina S</au><au>Gong, Yun</au><au>Lazar, Alexander J F</au><au>Diwan, A Hafeez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metastatic basal cell carcinoma exhibits reduced actin expression</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>21</volume><issue>5</issue><spage>540</spage><epage>543</epage><pages>540-543</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><coden>MODPEO</coden><abstract>Basal cell carcinoma is the most common malignancy in Caucasian individuals. Metastatic basal cell carcinoma is extremely rare (with a rate estimated as 0.03%). Actin has been detected in aggressive forms of basal cell carcinoma, but their expression in metastatic lesions is not known. We compared the expression of actin and actin-related cytoskeletal proteins in relatively less aggressive basal cell carcinoma (nodular), aggressive basal cell carcinoma (infiltrative/morpheaform), and metastatic basal cell carcinoma. We studied 12 cases of nodular basal cell carcinoma, 10 cases of infiltrative basal cell carcinoma, and 10 cases of metastatic basal cell carcinoma with immunohistochemistry for alpha-smooth muscle actin, calponin, myosin, and E-cadherin. Expression was interpreted as positive when at least 5% of the tumor exhibited at least weak expression. Five of the ten patients with metastatic basal cell carcinoma had an antecedent history of radiotherapy. Actin was present in 3 of 12 (25%) of the nodular, all 10 of the infiltrative, and 3 of 10 of the metastatic basal cell carcinomas (P<0.05 for metastatic vs infiltrative and nodular vs infiltrative). Calponin was present in 50% of the nodular, 60% of the infiltrative, and 30% of the metastatic basal cell carcinomas (not statistically significant). Myosin expression was not detected in any of the cases. E-cadherin was present in 75% of the nodular, 70% of the infiltrative, and all of the metastatic basal cell carcinomas (P<0.05 for metastatic vs nodular). Our results suggest that increased actin may contribute to local invasiveness, but it is lost in the metastatic phenotype. History of previous radiotherapy may contribute to development of the metastatic phenotype.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>18223552</pmid><doi>10.1038/modpathol.3801051</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | actin Actins - biosynthesis Adult Aged Aged, 80 and over basal cell carcinoma Cadherins - biosynthesis Calcium-Binding Proteins - biosynthesis Calponins Cancer Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Female Genotype & phenotype Humans Immunohistochemistry Laboratory Medicine Male Medical prognosis Medicine Medicine & Public Health Metastasis Microfilament Proteins - biosynthesis Middle Aged Monoclonal antibodies Myosins - biosynthesis Neoplasm Invasiveness original-article Pathology Radiation therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Smooth muscle Tumors White people |
| title | Metastatic basal cell carcinoma exhibits reduced actin expression |
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