Poly(ethylene glycol) derivative of cholesterol reduces binding step of liposome uptake by murine macrophage-like cell line J774 and human hepatoma cell line HepG2

Liposome uptake by HepG2 human hepatoma cells was investigated in comparison with the uptake by J774 murine macrophage-like cells. HepG2 cells accumulated liposomes (egg yolk phosphatidylcholine (EPC)/Chol; 75/25, diameter 0.2 micron) at 37 degrees C comparably to J774 macrophage-like cells. Confoca...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1998, Vol.46 (12), p.1907-1913
Hauptverfasser:	ISHIWATA, H, SATO, S. B, KOBAYASHI, S, OKU, M, VERTUT-DOÏ, A, MIYAJIMA, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein E3 Apolipoproteins E - metabolism Biological and medical sciences Cell Line Cholesterol - analogs & derivatives Cholesterol - pharmacology Endocytosis General pharmacology Humans Liposomes Medical sciences Mice Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - pharmacology Pronase - pharmacology Protein Binding Tumor Cells, Cultured
Online-Zugang:	Volltext
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