Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo

Myocardial infarction, stroke, and sudden death undergo diurnal variation. Although genes relevant to hemostasis and vascular integrity undergo circadian oscillation, the role of the molecular clock in thrombotic events remains to be established. A diurnal variation in the time to thrombotic vascula...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2008-04, Vol.117 (16), p.2087-2095
Hauptverfasser:	WESTGATE, Elizabeth J, YAN CHENG, REILLY, Dermot F, PRICE, Tom S, WALISSER, Jacqueline A, BRADFIELD, Christopher A, FITZGERALD, Garret A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARNTL Transcription Factors Basic Helix-Loop-Helix Transcription Factors - genetics Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Cardiology. Vascular system Circadian Rhythm - genetics CLOCK Proteins Death, Sudden, Cardiac Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelium, Vascular - physiology Fibrinolysis - physiology Gene Expression - physiology Heart Rate - physiology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Myocardial Infarction - genetics Myocardial Infarction - physiopathology Nerve Tissue Proteins - genetics Neurology Sympathetic Nervous System - physiology Telemetry Thrombosis - genetics Thrombosis - physiopathology Trans-Activators - genetics Vascular diseases and vascular malformations of the nervous system
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