Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve

Oligodendrocyte-specific protein (OSP) is a candidate autoantigen in the development of multiple sclerosis (MS). We evaluated the potential of OSP to induce EAE in rhesus monkeys, an out bred animal model for MS that is immunologically close to humans. Since OSP is a four-membrane spanning protein w...

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Veröffentlicht in:	European journal of immunology 2008-05, Vol.38 (5), p.1452-1464
Hauptverfasser:	Bajramovic, Jeffrey J, Brok, Herbert P.M, Ouwerling, Boudewijn, Jagessar, S. Anwar, van Straalen, Linda, Kondova, Ivanela, Bauer, Jan, Amor, Sandra, Hart, Bert A. 't, Ben-Nun, Avraham
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal models Animals Antibody Formation - immunology Autoimmunity Blindness - etiology Blindness - pathology Central Nervous System - pathology Claudins Cytokines - metabolism Demyelinating Diseases - pathology Encephalomyelitis, Autoimmune, Experimental - complications Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Epitopes, B-Lymphocyte - immunology Epitopes, T-Lymphocyte - immunology Female Humans Immunopathology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocyte Activation - immunology Macaca mulatta Molecular Sequence Data Multiple Sclerosis - immunology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Neuroimmunology Optic Nerve - pathology Peptide Fragments - genetics Peptide Fragments - immunology Recombinant Proteins - immunology Sequence Homology, Amino Acid Spleen - cytology Spleen - immunology Spleen - metabolism T-Lymphocytes - immunology Vaccination
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