Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects
Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolari...
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| Veröffentlicht in: | British journal of nutrition 2008-06, Vol.99 (6), p.1301-1309 |
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| creator | Zhang, Wei Wang, Xiaobing Liu, Yi Tian, Haimei Flickinger, Brent Empie, Mark W. Sun, Sam Z. |
| description | Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P |
| doi_str_mv | 10.1017/S0007114507871649 |
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An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0·05 to < 0·001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22·0 to 24·38 % respectively (all P < 0·005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations ≥ 5·83 mmol/l (lowered 25·56 and 24·96 %; P = 0·015 and P = 0·012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0·128–0·302; P < 0·05 to < 0·001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114507871649</identifier><identifier>PMID: 18053310</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; adults ; Alanine Transaminase - blood ; Biological and medical sciences ; blood glucose ; Blood Glucose - analysis ; Butylene Glycols - administration & dosage ; Cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Creatinine - blood ; Dietary Fiber - administration & dosage ; dietary nutrient sources ; dose response ; Double-Blind Method ; enterodiol ; enterolactone ; Feeding. Feeding behavior ; Female ; Flax ; Flaxseed lignans ; Fundamental and applied biological sciences. Psychology ; gamma-Glutamyltransferase - blood ; Genetic diversity ; Glucose ; Glucosides - administration & dosage ; Humans ; hypercholesterolemia ; Hypercholesterolemia - blood ; Hypercholesterolemia - diet therapy ; lignans ; Linear Models ; linseed ; Lipids ; Male ; Middle Aged ; Nitrogen - blood ; Nutrition ; nutritional intervention ; plant estrogens ; Plant Extracts - administration & dosage ; Plasma ; Secoisolariciresinol diglucoside ; Studies ; Triglycerides - blood ; Urea - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2008-06, Vol.99 (6), p.1301-1309</ispartof><rights>Copyright © The Authors 2007</rights><rights>2008 INIST-CNRS</rights><rights>The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-497d76586dbbba193b141383bb206b78c95fc674d5fb2fc22b6c1def0446b67e3</citedby><cites>FETCH-LOGICAL-c571t-497d76586dbbba193b141383bb206b78c95fc674d5fb2fc22b6c1def0446b67e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114507871649/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,777,781,27905,27906,55609</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20316900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18053310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Wang, Xiaobing</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><creatorcontrib>Tian, Haimei</creatorcontrib><creatorcontrib>Flickinger, Brent</creatorcontrib><creatorcontrib>Empie, Mark W.</creatorcontrib><creatorcontrib>Sun, Sam Z.</creatorcontrib><title>Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0·05 to < 0·001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22·0 to 24·38 % respectively (all P < 0·005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations ≥ 5·83 mmol/l (lowered 25·56 and 24·96 %; P = 0·015 and P = 0·012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0·128–0·302; P < 0·05 to < 0·001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner.</description><subject>Adult</subject><subject>adults</subject><subject>Alanine Transaminase - blood</subject><subject>Biological and medical sciences</subject><subject>blood glucose</subject><subject>Blood Glucose - analysis</subject><subject>Butylene Glycols - administration & dosage</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Creatinine - blood</subject><subject>Dietary Fiber - administration & dosage</subject><subject>dietary nutrient sources</subject><subject>dose response</subject><subject>Double-Blind Method</subject><subject>enterodiol</subject><subject>enterolactone</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Flax</subject><subject>Flaxseed lignans</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Genetic diversity</subject><subject>Glucose</subject><subject>Glucosides - administration & dosage</subject><subject>Humans</subject><subject>hypercholesterolemia</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - diet therapy</subject><subject>lignans</subject><subject>Linear Models</subject><subject>linseed</subject><subject>Lipids</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitrogen - blood</subject><subject>Nutrition</subject><subject>nutritional intervention</subject><subject>plant estrogens</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plasma</subject><subject>Secoisolariciresinol diglucoside</subject><subject>Studies</subject><subject>Triglycerides - blood</subject><subject>Urea - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kstu1DAUhi0EokPhAdiAhVR2AV9iO15WpR2QKi4qFUvLdpypByce7ASmb4-jiVoEYmUd_d-5_ccAPMfoDUZYvL1CCAmMa4ZEIzCv5QOwwrVgFeGcPASrWa5m_Qg8yXlbwgYj-Rgc4QYxSjFagZ_vvBt1uoVd0PvsXAuD3wx6gG4_Jm1HGOIvlzLcBZ17De1NDC6PLsUA9dDCTZhszA7aOFg3lIzRxyFDP8Cb251Lf-Da9d7CPJmts2N-Ch51OmT3bHmPwfXF-dez99Xlp_WHs9PLyjKBx6qWohWcNbw1xmgsqcE1pg01hiBuRGMl6ywXdcs6QzpLiOEWt65Ddc0NF44eg9eHursUf0xlFNX7bF0IenBxyopLTDijooCv_gK3cUpDmU2R0pHIWrIC4QNkU8w5uU7tku-LewojNV9E_XORkvNiKTyZ3rX3GcsJCnCyADpbHbqkB-vzHUcQxVyimasOnC-G7u90nb4rLqhgiq-_KHbxmXxbf2RqbvzywHc6Kr1Jpeb1FUGYll8gRXG1EHRZR_cm-Xbj7pf-_0K_AXLEvLI</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Zhang, Wei</creator><creator>Wang, Xiaobing</creator><creator>Liu, Yi</creator><creator>Tian, Haimei</creator><creator>Flickinger, Brent</creator><creator>Empie, Mark W.</creator><creator>Sun, Sam Z.</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects</title><author>Zhang, Wei ; Wang, Xiaobing ; Liu, Yi ; Tian, Haimei ; Flickinger, Brent ; Empie, Mark W. ; Sun, Sam Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-497d76586dbbba193b141383bb206b78c95fc674d5fb2fc22b6c1def0446b67e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>adults</topic><topic>Alanine Transaminase - blood</topic><topic>Biological and medical sciences</topic><topic>blood glucose</topic><topic>Blood Glucose - analysis</topic><topic>Butylene Glycols - administration & dosage</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Creatinine - blood</topic><topic>Dietary Fiber - administration & dosage</topic><topic>dietary nutrient sources</topic><topic>dose response</topic><topic>Double-Blind Method</topic><topic>enterodiol</topic><topic>enterolactone</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Flax</topic><topic>Flaxseed lignans</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Glutamyltransferase - blood</topic><topic>Genetic diversity</topic><topic>Glucose</topic><topic>Glucosides - administration & dosage</topic><topic>Humans</topic><topic>hypercholesterolemia</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - diet therapy</topic><topic>lignans</topic><topic>Linear Models</topic><topic>linseed</topic><topic>Lipids</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitrogen - blood</topic><topic>Nutrition</topic><topic>nutritional intervention</topic><topic>plant estrogens</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plasma</topic><topic>Secoisolariciresinol diglucoside</topic><topic>Studies</topic><topic>Triglycerides - blood</topic><topic>Urea - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Wang, Xiaobing</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><creatorcontrib>Tian, Haimei</creatorcontrib><creatorcontrib>Flickinger, Brent</creatorcontrib><creatorcontrib>Empie, Mark W.</creatorcontrib><creatorcontrib>Sun, Sam Z.</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Wei</au><au>Wang, Xiaobing</au><au>Liu, Yi</au><au>Tian, Haimei</au><au>Flickinger, Brent</au><au>Empie, Mark W.</au><au>Sun, Sam Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>99</volume><issue>6</issue><spage>1301</spage><epage>1309</epage><pages>1301-1309</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0·05 to < 0·001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22·0 to 24·38 % respectively (all P < 0·005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations ≥ 5·83 mmol/l (lowered 25·56 and 24·96 %; P = 0·015 and P = 0·012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0·128–0·302; P < 0·05 to < 0·001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>18053310</pmid><doi>10.1017/S0007114507871649</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult adults Alanine Transaminase - blood Biological and medical sciences blood glucose Blood Glucose - analysis Butylene Glycols - administration & dosage Cholesterol Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Creatinine - blood Dietary Fiber - administration & dosage dietary nutrient sources dose response Double-Blind Method enterodiol enterolactone Feeding. Feeding behavior Female Flax Flaxseed lignans Fundamental and applied biological sciences. Psychology gamma-Glutamyltransferase - blood Genetic diversity Glucose Glucosides - administration & dosage Humans hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - diet therapy lignans Linear Models linseed Lipids Male Middle Aged Nitrogen - blood Nutrition nutritional intervention plant estrogens Plant Extracts - administration & dosage Plasma Secoisolariciresinol diglucoside Studies Triglycerides - blood Urea - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects |
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