Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects

Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolari...

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Veröffentlicht in:	British journal of nutrition 2008-06, Vol.99 (6), p.1301-1309
Hauptverfasser:	Zhang, Wei, Wang, Xiaobing, Liu, Yi, Tian, Haimei, Flickinger, Brent, Empie, Mark W., Sun, Sam Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult adults Alanine Transaminase - blood Biological and medical sciences blood glucose Blood Glucose - analysis Butylene Glycols - administration & dosage Cholesterol Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Creatinine - blood Dietary Fiber - administration & dosage dietary nutrient sources dose response Double-Blind Method enterodiol enterolactone Feeding. Feeding behavior Female Flax Flaxseed lignans Fundamental and applied biological sciences. Psychology gamma-Glutamyltransferase - blood Genetic diversity Glucose Glucosides - administration & dosage Humans hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - diet therapy lignans Linear Models linseed Lipids Male Middle Aged Nitrogen - blood Nutrition nutritional intervention plant estrogens Plant Extracts - administration & dosage Plasma Secoisolariciresinol diglucoside Studies Triglycerides - blood Urea - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P
ISSN:	0007-1145 1475-2662
DOI:	10.1017/S0007114507871649