Cannabinoid Type 1 Receptor: Another Arrow in the Adipocytes' Bow

The endocannabinoid system has recently emerged as an important modulator of several functions of adipose tissue, including cell proliferation, differentiation and secretion. Here, we will review the effects of cannabinoid type 1 (CB1) receptor activation/blockade in adipocytes by summarising the da...

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Veröffentlicht in:	Journal of neuroendocrinology 2008-05, Vol.20 (s1), p.130-138
Hauptverfasser:	Bellocchio, L., Cervino, C., Vicennati, V., Pasquali, R., Pagotto, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocyte Adipocytes - metabolism Adipogenesis - drug effects Adipogenesis - physiology Adipokines - metabolism adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose Tissue - physiology Animals Benzoxazines - pharmacology Biological and medical sciences Cannabinoid Receptor Modulators - metabolism Cannabinoid Receptor Modulators - physiology cannabinoid receptor type 1 Cannabinoids - antagonists & inhibitors Cannabinoids - pharmacology Cell Differentiation - drug effects Cell Proliferation - drug effects Fundamental and applied biological sciences. Psychology Humans Lipid Metabolism - drug effects Lipid Metabolism - physiology Medical sciences Metabolic diseases Morpholines - pharmacology Naphthalenes - pharmacology Obesity Piperidines - pharmacology Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB1 - physiology Rimonabant Vertebrates: endocrinology
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Zusammenfassung:	The endocannabinoid system has recently emerged as an important modulator of several functions of adipose tissue, including cell proliferation, differentiation and secretion. Here, we will review the effects of cannabinoid type 1 (CB1) receptor activation/blockade in adipocytes by summarising the data in the literature since the discovery of the presence of this receptor in adipose tissue. We will also discuss our original data obtained in mouse 3T3‐L1 adipocyte cells using WIN55 212, a CB1/CB2 receptor agonist and SR141716 (rimonabant), a specific CB1 receptor antagonist, respectively, in different experimental settings.
ISSN:	0953-8194 1365-2826
DOI:	10.1111/j.1365-2826.2008.01682.x