Variant form of STAT4 is associated with primary Sjögren's syndrome
Single nucleotide polymorphisms in the STAT4 gene have recently been shown to be associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Primary Sjögren's sydrome (pSS) is a related autoimmune disease thought to have a pathogenesis similar to these diseases. To test th...
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| Veröffentlicht in: | Genes and immunity 2008-04, Vol.9 (3), p.267-270 |
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| creator | Korman, B D Alba, M I Le, J M Alevizos, I Smith, J A Nikolov, N P Kastner, D L Remmers, E F Illei, G G |
| description | Single nucleotide polymorphisms in the
STAT4
gene have recently been shown to be associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Primary Sjögren's sydrome (pSS) is a related autoimmune disease thought to have a pathogenesis similar to these diseases. To test the hypothesis that the variant haplotype of
STAT4
seen in RA and SLE is also associated with pSS, we genotyped rs7574865, the most strongly disease-associated SNP in the variant
STAT4
haplotype, in 124 Caucasian pSS subjects and compared them to 1143 Caucasian controls. The disease-associated T allele was more common in chromosomes of the pSS patients (29.6%) than in controls (22.3%), leading to a
P
-value for association of 0.01. These results implicate polymorphisms in the
STAT4
gene in the pathogenesis of pSS. |
| doi_str_mv | 10.1038/gene.2008.1 |
| format | Article |
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STAT4
gene have recently been shown to be associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Primary Sjögren's sydrome (pSS) is a related autoimmune disease thought to have a pathogenesis similar to these diseases. To test the hypothesis that the variant haplotype of
STAT4
seen in RA and SLE is also associated with pSS, we genotyped rs7574865, the most strongly disease-associated SNP in the variant
STAT4
haplotype, in 124 Caucasian pSS subjects and compared them to 1143 Caucasian controls. The disease-associated T allele was more common in chromosomes of the pSS patients (29.6%) than in controls (22.3%), leading to a
P
-value for association of 0.01. These results implicate polymorphisms in the
STAT4
gene in the pathogenesis of pSS.</description><identifier>ISSN: 1466-4879</identifier><identifier>EISSN: 1476-5470</identifier><identifier>DOI: 10.1038/gene.2008.1</identifier><identifier>PMID: 18273036</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Aged ; Autoimmune diseases ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Chromosomes ; Complications and side effects ; Diagnosis ; Disease ; European Continental Ancestry Group - genetics ; Female ; Gene Expression ; Gene Frequency ; Genetic aspects ; Genotype ; Haplotypes ; Haplotypes - genetics ; Human Genetics ; Humans ; Immunology ; Male ; Middle Aged ; Pathogenesis ; Polymorphism, Single Nucleotide - genetics ; Rheumatoid arthritis ; Risk factors ; short-communication ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Sjogren's syndrome ; Sjogren's Syndrome - genetics ; Stat4 protein ; STAT4 Transcription Factor - genetics ; Systemic lupus erythematosus ; White people</subject><ispartof>Genes and immunity, 2008-04, Vol.9 (3), p.267-270</ispartof><rights>Springer Nature Limited 2008</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2008</rights><rights>Nature Publishing Group 2008.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-7db4ee270db3af4082262731e594a0d8b71149a8f76fd2d40678de1b0c587fa63</citedby><cites>FETCH-LOGICAL-c480t-7db4ee270db3af4082262731e594a0d8b71149a8f76fd2d40678de1b0c587fa63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/gene.2008.1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/gene.2008.1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18273036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korman, B D</creatorcontrib><creatorcontrib>Alba, M I</creatorcontrib><creatorcontrib>Le, J M</creatorcontrib><creatorcontrib>Alevizos, I</creatorcontrib><creatorcontrib>Smith, J A</creatorcontrib><creatorcontrib>Nikolov, N P</creatorcontrib><creatorcontrib>Kastner, D L</creatorcontrib><creatorcontrib>Remmers, E F</creatorcontrib><creatorcontrib>Illei, G G</creatorcontrib><title>Variant form of STAT4 is associated with primary Sjögren's syndrome</title><title>Genes and immunity</title><addtitle>Genes Immun</addtitle><addtitle>Genes Immun</addtitle><description>Single nucleotide polymorphisms in the
STAT4
gene have recently been shown to be associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Primary Sjögren's sydrome (pSS) is a related autoimmune disease thought to have a pathogenesis similar to these diseases. To test the hypothesis that the variant haplotype of
STAT4
seen in RA and SLE is also associated with pSS, we genotyped rs7574865, the most strongly disease-associated SNP in the variant
STAT4
haplotype, in 124 Caucasian pSS subjects and compared them to 1143 Caucasian controls. The disease-associated T allele was more common in chromosomes of the pSS patients (29.6%) than in controls (22.3%), leading to a
P
-value for association of 0.01. These results implicate polymorphisms in the
STAT4
gene in the pathogenesis of pSS.</description><subject>Adult</subject><subject>Aged</subject><subject>Autoimmune diseases</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Chromosomes</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Rheumatoid arthritis</subject><subject>Risk factors</subject><subject>short-communication</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Sjogren's syndrome</subject><subject>Sjogren's Syndrome - genetics</subject><subject>Stat4 protein</subject><subject>STAT4 Transcription Factor - genetics</subject><subject>Systemic lupus erythematosus</subject><subject>White people</subject><issn>1466-4879</issn><issn>1476-5470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kt-K1DAUxoMo7rp65b0UBUW0Y06bJunlsOufhQXBGb0NaXNSO0yT3aTF3RfzBXwxU2ZgGFnJRULyO1--w_kIeQ50AbSUHzp0uCgolQt4QE6BCZ5XTNCH85nznElRn5AnMW4oBQ68fkxOQBaipCU_JRc_dOi1GzPrw5B5m63WyzXL-pjpGH3b6xFN9qsff2bXoR90uMtWmz-_u4DuTczinTPBD_iUPLJ6G_HZfj8j3z99XJ9_ya--fr48X17lLZN0zIVpGGIhqGlKbRmVRcGTD8CqZpoa2QgAVmtpBbemMIxyIQ1CQ9tKCqt5eUZe73Svg7-ZMI5q6GOL26126KeoeA1FBbJM4Kt_wI2fgkveVMEZiEJWZZ2ol_-lQMoaaA0HqU5vUfXO-jHodv5XLUHUHCouZqnFPVRaBoe-9Q5tn-6PCt4eFSRmxNux01OM6nL17Zh9t2Pb4GMMaNV-FgqomiOg5gioOQJqNvxi39XUDGgO7H7mCXi_A2J6ch2GQ9v36f0FBwW25Q</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Korman, B D</creator><creator>Alba, M I</creator><creator>Le, J M</creator><creator>Alevizos, I</creator><creator>Smith, J A</creator><creator>Nikolov, N P</creator><creator>Kastner, D L</creator><creator>Remmers, E F</creator><creator>Illei, G G</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Variant form of STAT4 is associated with primary Sjögren's syndrome</title><author>Korman, B D ; Alba, M I ; Le, J M ; Alevizos, I ; Smith, J A ; Nikolov, N P ; Kastner, D L ; Remmers, E F ; Illei, G G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-7db4ee270db3af4082262731e594a0d8b71149a8f76fd2d40678de1b0c587fa63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Autoimmune diseases</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Chromosomes</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>European Continental Ancestry Group - 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Academic</collection><jtitle>Genes and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korman, B D</au><au>Alba, M I</au><au>Le, J M</au><au>Alevizos, I</au><au>Smith, J A</au><au>Nikolov, N P</au><au>Kastner, D L</au><au>Remmers, E F</au><au>Illei, G G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variant form of STAT4 is associated with primary Sjögren's syndrome</atitle><jtitle>Genes and immunity</jtitle><stitle>Genes Immun</stitle><addtitle>Genes Immun</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>9</volume><issue>3</issue><spage>267</spage><epage>270</epage><pages>267-270</pages><issn>1466-4879</issn><eissn>1476-5470</eissn><abstract>Single nucleotide polymorphisms in the
STAT4
gene have recently been shown to be associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Primary Sjögren's sydrome (pSS) is a related autoimmune disease thought to have a pathogenesis similar to these diseases. To test the hypothesis that the variant haplotype of
STAT4
seen in RA and SLE is also associated with pSS, we genotyped rs7574865, the most strongly disease-associated SNP in the variant
STAT4
haplotype, in 124 Caucasian pSS subjects and compared them to 1143 Caucasian controls. The disease-associated T allele was more common in chromosomes of the pSS patients (29.6%) than in controls (22.3%), leading to a
P
-value for association of 0.01. These results implicate polymorphisms in the
STAT4
gene in the pathogenesis of pSS.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18273036</pmid><doi>10.1038/gene.2008.1</doi><tpages>4</tpages></addata></record> |
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| ispartof | Genes and immunity, 2008-04, Vol.9 (3), p.267-270 |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Autoimmune diseases Biomedical and Life Sciences Biomedicine Cancer Research Chromosomes Complications and side effects Diagnosis Disease European Continental Ancestry Group - genetics Female Gene Expression Gene Frequency Genetic aspects Genotype Haplotypes Haplotypes - genetics Human Genetics Humans Immunology Male Middle Aged Pathogenesis Polymorphism, Single Nucleotide - genetics Rheumatoid arthritis Risk factors short-communication Single nucleotide polymorphisms Single-nucleotide polymorphism Sjogren's syndrome Sjogren's Syndrome - genetics Stat4 protein STAT4 Transcription Factor - genetics Systemic lupus erythematosus White people |
| title | Variant form of STAT4 is associated with primary Sjögren's syndrome |
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