Overcoming the formulation obstacles towards targeted chemotherapy: In vitro and in vivo evaluation of cytotoxic drug loaded immunonanoparticles

The aim of this study was to design a new one step conjugation of monoclonal antibodies (MAbs) to surface activated pegylated polyester nanoparticles (NPs) and evaluate the pharmacokinetic profile and therapeutic effect of paclitaxel palmitate (pcpl) loaded anti-HER2 immunoNPs in mice as compared to...

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Veröffentlicht in:	Journal of controlled release 2008-05, Vol.127 (3), p.219-230
Hauptverfasser:	Debotton, Nir, Parnes, Marcela, Kadouche, Jean, Benita, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-tumor Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Cell Line, Tumor Docetaxel Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Carriers - therapeutic use General pharmacology Humans Immunonanoparticles Male Medical sciences Mice Mice, Inbred BALB C Mice, SCID Monoclonal antibodies Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Paclitaxel - chemistry Paclitaxel - pharmacokinetics Paclitaxel - therapeutic use Paclitaxel palmitate Palmitates - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments Polyesters - chemistry Polyethylene Glycols - chemistry Receptor, ErbB-2 - immunology Receptor, ErbB-2 - metabolism Sulfhydryl Compounds - chemistry Tissue Distribution Trastuzumab Tumor Burden - drug effects Xenograft Model Antitumor Assays
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