Defects of mitochondrial respiratory chain in multiple symmetric lipomatosis
Using lymphocytes from nine unrelated patients with multiple symmetric lipomatosis we investigated a possible defect in the mitochondrial respiratory chain as the biochemical cause for the disease. A significant decrease in oxygen consumption of intact lymphocytes as well as a decreased activity of...
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| Veröffentlicht in: | Archives of Dermatological Research 1998-12, Vol.290 (12), p.652-655 |
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| container_end_page | 655 |
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| container_issue | 12 |
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| container_title | Archives of Dermatological Research |
| container_volume | 290 |
| creator | BECKER-WEGERICH, P STEUBER, M OLBRISCH, R RUZICKA, T AUBURGER, G HOFHAUS, G |
| description | Using lymphocytes from nine unrelated patients with multiple symmetric lipomatosis we investigated a possible defect in the mitochondrial respiratory chain as the biochemical cause for the disease. A significant decrease in oxygen consumption of intact lymphocytes as well as a decreased activity of the individual components of the respiratory chain were detected. These findings are consistent with the recently described deletions and point mutations of mitochondrial DNA in patients suffering from this disease. |
| doi_str_mv | 10.1007/s004030050368 |
| format | Article |
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A significant decrease in oxygen consumption of intact lymphocytes as well as a decreased activity of the individual components of the respiratory chain were detected. These findings are consistent with the recently described deletions and point mutations of mitochondrial DNA in patients suffering from this disease.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s004030050368</identifier><identifier>PMID: 9879833</identifier><identifier>CODEN: ADREDL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Dermatology ; DNA, Mitochondrial - analysis ; Electron Transport ; Female ; Humans ; Lipomatosis, Multiple Symmetrical - metabolism ; Male ; Medical sciences ; Middle Aged ; Mitochondria - metabolism ; Oxygen Consumption ; Tumors of the skin and soft tissue. 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A significant decrease in oxygen consumption of intact lymphocytes as well as a decreased activity of the individual components of the respiratory chain were detected. These findings are consistent with the recently described deletions and point mutations of mitochondrial DNA in patients suffering from this disease.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>DNA, Mitochondrial - analysis</subject><subject>Electron Transport</subject><subject>Female</subject><subject>Humans</subject><subject>Lipomatosis, Multiple Symmetrical - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitochondria - metabolism</subject><subject>Oxygen Consumption</subject><subject>Tumors of the skin and soft tissue. 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| ispartof | Archives of Dermatological Research, 1998-12, Vol.290 (12), p.652-655 |
| issn | 0340-3696 1432-069X |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Biological and medical sciences Dermatology DNA, Mitochondrial - analysis Electron Transport Female Humans Lipomatosis, Multiple Symmetrical - metabolism Male Medical sciences Middle Aged Mitochondria - metabolism Oxygen Consumption Tumors of the skin and soft tissue. Premalignant lesions |
| title | Defects of mitochondrial respiratory chain in multiple symmetric lipomatosis |
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