Distinct neurophysiological mechanisms for manic and cycloid psychoses: evidence from a P300 study on manic patients
Pathologically asymmetrical P300 fields with right lateralized peaks were described in core schizophrenia as an expression of left‐temporal functional deficits, while higher than normal amplitudes were found in cycloid psychosis. This latter finding appeared to be specific for cycloid psychosis and...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 1998-12, Vol.98 (6), p.459-466 |
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| container_title | Acta psychiatrica Scandinavica |
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| creator | Strik, W. K. Ruchsow, M. Abele, S. Fallgatter, A. J. Mueller, Th. J. |
| description | Pathologically asymmetrical P300 fields with right lateralized peaks were described in core schizophrenia as an expression of left‐temporal functional deficits, while higher than normal amplitudes were found in cycloid psychosis. This latter finding appeared to be specific for cycloid psychosis and was explained by a generalized cerebral hyperarousal. Based on some psychopathological analogies with cycloid psychosis, and on the comparable pharmacological treatment of the acute episodes, a group of 19 manic patients was investigated immediately after remission and clinical stabilization of an episode. Patients with psychotic features were excluded to avoid overlaps with cycloid psychosis. Patients showed normal P300 amplitudes and no pathological asymmetries of the field, but more posterior positive areas compared to age‐ and sex‐matched controls. This indicates that the neurophysiological changes underlying mania are different from both core schizophrenia and cycloid psychosis. Based on previous three‐dimensional source location studies, this finding indicates that disinhibition due to reduced frontal lobe activity, and not hyperarousal, is the basic functional mechanism of manic disorders. |
| doi_str_mv | 10.1111/j.1600-0447.1998.tb10120.x |
| format | Article |
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K. ; Ruchsow, M. ; Abele, S. ; Fallgatter, A. J. ; Mueller, Th. J.</creator><creatorcontrib>Strik, W. K. ; Ruchsow, M. ; Abele, S. ; Fallgatter, A. J. ; Mueller, Th. J.</creatorcontrib><description>Pathologically asymmetrical P300 fields with right lateralized peaks were described in core schizophrenia as an expression of left‐temporal functional deficits, while higher than normal amplitudes were found in cycloid psychosis. This latter finding appeared to be specific for cycloid psychosis and was explained by a generalized cerebral hyperarousal. Based on some psychopathological analogies with cycloid psychosis, and on the comparable pharmacological treatment of the acute episodes, a group of 19 manic patients was investigated immediately after remission and clinical stabilization of an episode. Patients with psychotic features were excluded to avoid overlaps with cycloid psychosis. Patients showed normal P300 amplitudes and no pathological asymmetries of the field, but more posterior positive areas compared to age‐ and sex‐matched controls. This indicates that the neurophysiological changes underlying mania are different from both core schizophrenia and cycloid psychosis. Based on previous three‐dimensional source location studies, this finding indicates that disinhibition due to reduced frontal lobe activity, and not hyperarousal, is the basic functional mechanism of manic disorders.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/j.1600-0447.1998.tb10120.x</identifier><identifier>PMID: 9879788</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; Adolescent ; Adult ; Adult and adolescent clinical studies ; affective disorders ; Arousal - physiology ; Biological and medical sciences ; Bipolar Disorder - diagnosis ; Bipolar Disorder - physiopathology ; Bipolar Disorder - psychology ; bipolar disorders ; cycloid psychosis ; Event-Related Potentials, P300 ; evoked potentials ; Female ; Frontal Lobe - physiopathology ; Functional Laterality ; Humans ; Male ; Mania ; Medical sciences ; Middle Aged ; Mood disorders ; Neurophysiology ; P300 ; Periodicity ; Psychiatric Status Rating Scales ; Psychology. 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Psychiatry ; Psychotic Disorders - diagnosis ; Psychotic Disorders - physiopathology ; Psychotic Disorders - psychology ; Schizophrenia - diagnosis ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Temporal Lobe - physiopathology</subject><ispartof>Acta psychiatrica Scandinavica, 1998-12, Vol.98 (6), p.459-466</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5039-de3317dc09c65ccaddd924d6ec60ac476a9ebadfbcfb28a67fcb8a09be4cd1033</citedby><cites>FETCH-LOGICAL-c5039-de3317dc09c65ccaddd924d6ec60ac476a9ebadfbcfb28a67fcb8a09be4cd1033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0447.1998.tb10120.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0447.1998.tb10120.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1621415$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9879788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strik, W. K.</creatorcontrib><creatorcontrib>Ruchsow, M.</creatorcontrib><creatorcontrib>Abele, S.</creatorcontrib><creatorcontrib>Fallgatter, A. J.</creatorcontrib><creatorcontrib>Mueller, Th. J.</creatorcontrib><title>Distinct neurophysiological mechanisms for manic and cycloid psychoses: evidence from a P300 study on manic patients</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Pathologically asymmetrical P300 fields with right lateralized peaks were described in core schizophrenia as an expression of left‐temporal functional deficits, while higher than normal amplitudes were found in cycloid psychosis. This latter finding appeared to be specific for cycloid psychosis and was explained by a generalized cerebral hyperarousal. Based on some psychopathological analogies with cycloid psychosis, and on the comparable pharmacological treatment of the acute episodes, a group of 19 manic patients was investigated immediately after remission and clinical stabilization of an episode. Patients with psychotic features were excluded to avoid overlaps with cycloid psychosis. Patients showed normal P300 amplitudes and no pathological asymmetries of the field, but more posterior positive areas compared to age‐ and sex‐matched controls. This indicates that the neurophysiological changes underlying mania are different from both core schizophrenia and cycloid psychosis. Based on previous three‐dimensional source location studies, this finding indicates that disinhibition due to reduced frontal lobe activity, and not hyperarousal, is the basic functional mechanism of manic disorders.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>affective disorders</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Bipolar Disorder - psychology</subject><subject>bipolar disorders</subject><subject>cycloid psychosis</subject><subject>Event-Related Potentials, P300</subject><subject>evoked potentials</subject><subject>Female</subject><subject>Frontal Lobe - physiopathology</subject><subject>Functional Laterality</subject><subject>Humans</subject><subject>Male</subject><subject>Mania</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Neurophysiology</subject><subject>P300</subject><subject>Periodicity</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychotic Disorders - diagnosis</subject><subject>Psychotic Disorders - physiopathology</subject><subject>Psychotic Disorders - psychology</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Temporal Lobe - physiopathology</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkVuP1CAYhonRrOPqTzAhxuxdK_RAy96Yzai7mo1OPMS5I_SDOowtVGh1-u9lMs14LTdA3sNHHhB6QUlK43q1TykjJCFFUaWU8zodG0poRtLDA7Q6Sw_RihBCE8bJ9jF6EsI-XktK6gt0weuKV3W9QuMbE0ZjYcRWT94NuzkY17kfBmSHew07aU3oA26dx308A5ZWYZihc0bhIcywc0GHa6x_G6UtaNx612OJNzkhOIyTmrGzS3SQo9F2DE_Ro1Z2QT9b9kv07d3br-u75P7T7fv1zX0CJcl5onSe00oB4cBKAKmU4lmhmAZGJBQVk1w3UrUNtE1WS1a10NSS8EYXoCjJ80t0deodvPs16TCK3gTQXSetdlMQjNMsr7IsGq9PRvAuBK9bMXjTSz8LSsQRudiLI1dx5CqOyMWCXBxi-PkyZWp6rc7RhXHUXy66DJFq66UFE_5NYBktaBltr0-2P6bT8388QNysN1-KkseG5NQQv1Qfzg3S_xSsyqtSfP94Kz5si8_bcrMRd_lfhwawtQ</recordid><startdate>199812</startdate><enddate>199812</enddate><creator>Strik, W. K.</creator><creator>Ruchsow, M.</creator><creator>Abele, S.</creator><creator>Fallgatter, A. J.</creator><creator>Mueller, Th. J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199812</creationdate><title>Distinct neurophysiological mechanisms for manic and cycloid psychoses: evidence from a P300 study on manic patients</title><author>Strik, W. K. ; Ruchsow, M. ; Abele, S. ; Fallgatter, A. J. ; Mueller, Th. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5039-de3317dc09c65ccaddd924d6ec60ac476a9ebadfbcfb28a67fcb8a09be4cd1033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>affective disorders</topic><topic>Arousal - physiology</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Bipolar Disorder - psychology</topic><topic>bipolar disorders</topic><topic>cycloid psychosis</topic><topic>Event-Related Potentials, P300</topic><topic>evoked potentials</topic><topic>Female</topic><topic>Frontal Lobe - physiopathology</topic><topic>Functional Laterality</topic><topic>Humans</topic><topic>Male</topic><topic>Mania</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Neurophysiology</topic><topic>P300</topic><topic>Periodicity</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychotic Disorders - diagnosis</topic><topic>Psychotic Disorders - physiopathology</topic><topic>Psychotic Disorders - psychology</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Temporal Lobe - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strik, W. K.</creatorcontrib><creatorcontrib>Ruchsow, M.</creatorcontrib><creatorcontrib>Abele, S.</creatorcontrib><creatorcontrib>Fallgatter, A. J.</creatorcontrib><creatorcontrib>Mueller, Th. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strik, W. K.</au><au>Ruchsow, M.</au><au>Abele, S.</au><au>Fallgatter, A. J.</au><au>Mueller, Th. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct neurophysiological mechanisms for manic and cycloid psychoses: evidence from a P300 study on manic patients</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>1998-12</date><risdate>1998</risdate><volume>98</volume><issue>6</issue><spage>459</spage><epage>466</epage><pages>459-466</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Pathologically asymmetrical P300 fields with right lateralized peaks were described in core schizophrenia as an expression of left‐temporal functional deficits, while higher than normal amplitudes were found in cycloid psychosis. This latter finding appeared to be specific for cycloid psychosis and was explained by a generalized cerebral hyperarousal. Based on some psychopathological analogies with cycloid psychosis, and on the comparable pharmacological treatment of the acute episodes, a group of 19 manic patients was investigated immediately after remission and clinical stabilization of an episode. Patients with psychotic features were excluded to avoid overlaps with cycloid psychosis. Patients showed normal P300 amplitudes and no pathological asymmetries of the field, but more posterior positive areas compared to age‐ and sex‐matched controls. This indicates that the neurophysiological changes underlying mania are different from both core schizophrenia and cycloid psychosis. 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| subjects | Acute Disease Adolescent Adult Adult and adolescent clinical studies affective disorders Arousal - physiology Biological and medical sciences Bipolar Disorder - diagnosis Bipolar Disorder - physiopathology Bipolar Disorder - psychology bipolar disorders cycloid psychosis Event-Related Potentials, P300 evoked potentials Female Frontal Lobe - physiopathology Functional Laterality Humans Male Mania Medical sciences Middle Aged Mood disorders Neurophysiology P300 Periodicity Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotic Disorders - diagnosis Psychotic Disorders - physiopathology Psychotic Disorders - psychology Schizophrenia - diagnosis Schizophrenia - physiopathology Schizophrenic Psychology Temporal Lobe - physiopathology |
| title | Distinct neurophysiological mechanisms for manic and cycloid psychoses: evidence from a P300 study on manic patients |
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