Expression of adrenomedullin mRNA in adrenocortical tumors and secretion of adrenomedullin by cultured adrenocortical carcinoma cells

Immunoreactive-adrenomedullin concentrations and the expression of adrenomedullin mRNA were studied in the tumor tissues of adrenocortical tumors. Northern blot analysis showed the expression of adrenomedullin mRNA in tumor tissues of adrenocortical tumors, including aldosterone-producing adenomas,...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1998, Vol.19 (10), p.1719-1724
Hauptverfasser:	Takahashi, Kazuhiro, Satoh, Fumitoshi, Sone, Masahiko, Totsune, Kazuhito, Arihara, Zenei, Noshiro, Takao, Mouri, Toraichi, Murakami, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Adrenal Cortex Neoplasms - chemistry Adrenal Cortex Neoplasms - metabolism Adrenocortical Adrenomedullin Aldosterone Blotting, Northern Carcinoma Carcinoma - chemistry Carcinoma - metabolism Humans Northern blot Peptides - isolation & purification Peptides - metabolism Radioimmunoassay RNA, Messenger - analysis RNA, Messenger - biosynthesis Tumor Cells, Cultured
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Zusammenfassung:	Immunoreactive-adrenomedullin concentrations and the expression of adrenomedullin mRNA were studied in the tumor tissues of adrenocortical tumors. Northern blot analysis showed the expression of adrenomedullin mRNA in tumor tissues of adrenocortical tumors, including aldosterone-producing adenomas, cortisol-producing adenomas, a non-functioning adenoma and adrenocortical carcinomas, as well as normal parts of adrenal glands and pheochromocytomas. On the other hand, immunoreactive-adrenomedullin was not detected in about 90% cases of adrenocortical tumors (
ISSN:	0196-9781 1873-5169
DOI:	10.1016/S0196-9781(98)00128-4