Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta
This study investigated the possible active principles which support the endothelial nitric oxide-dependent relaxation produced by red wine and other plant polyphenolic compounds in thoracic aorta from male Wistar rats (12-14 wk old). Relaxation experiments were recorded isometrically on vessels pre...
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| Veröffentlicht in: | The Journal of Nutrition 1998-12, Vol.128 (12), p.2324-2333 |
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| container_title | The Journal of Nutrition |
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| creator | ANDRIAMBELOSON, E MAGNIER, C HAAN-ARCHIPOFF, G LOBSTEIN, A ANTON, R BERETZ, A STOCLET, J. C ANDRIANTSITOHAINA, R |
| description | This study investigated the possible active principles which support the endothelial nitric oxide-dependent relaxation produced by red wine and other plant polyphenolic compounds in thoracic aorta from male Wistar rats (12-14 wk old). Relaxation experiments were recorded isometrically on vessels precontracted with norepinephrine. Ten different chromatographic fractions (3-18 mg) isolated from red wine polyphenolic compounds (RWPC) and some available defined polyphenols (10-15 mg) were tested. Fractions enriched into either anthocyanins or oligomeric condensed tannins exhibited endothelium-dependent vasorelaxant activity (maximal relaxation in the range of 59-77%) comparable to the original RWPC. However, polymeric condensed tannins elicited a weaker vasorelaxant activity than the original RWPC (maximal relaxation ranged between 20-47%, P < 0.01). Moreover, the representative of either phenolic acid derivatives (benzoic acid, vanillic acid, gallic acid), hydroxycinnamic acid (p-coumaric acid, caffeic acid) or the flavanol [(+)-epicatechin] classes failed to induce this type of response. Among the anthocyanins, delphinidin (maximal relaxation being 89%), but not malvidin or cyanidin, showed endothelium-dependent vasorelaxation. These results show that anthocyanins and oligomeric-condensed tannins exhibited a pharmacological profile comparable to the original RWPC. These compounds may be involved in the reduction of cardiovascular mortality related to the presence of wine, fruits and vegetables in the diet. |
| doi_str_mv | 10.1093/jn/128.12.2324 |
| format | Article |
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C ; ANDRIANTSITOHAINA, R</creator><creatorcontrib>ANDRIAMBELOSON, E ; MAGNIER, C ; HAAN-ARCHIPOFF, G ; LOBSTEIN, A ; ANTON, R ; BERETZ, A ; STOCLET, J. C ; ANDRIANTSITOHAINA, R</creatorcontrib><description>This study investigated the possible active principles which support the endothelial nitric oxide-dependent relaxation produced by red wine and other plant polyphenolic compounds in thoracic aorta from male Wistar rats (12-14 wk old). Relaxation experiments were recorded isometrically on vessels precontracted with norepinephrine. Ten different chromatographic fractions (3-18 mg) isolated from red wine polyphenolic compounds (RWPC) and some available defined polyphenols (10-15 mg) were tested. Fractions enriched into either anthocyanins or oligomeric condensed tannins exhibited endothelium-dependent vasorelaxant activity (maximal relaxation in the range of 59-77%) comparable to the original RWPC. However, polymeric condensed tannins elicited a weaker vasorelaxant activity than the original RWPC (maximal relaxation ranged between 20-47%, P < 0.01). Moreover, the representative of either phenolic acid derivatives (benzoic acid, vanillic acid, gallic acid), hydroxycinnamic acid (p-coumaric acid, caffeic acid) or the flavanol [(+)-epicatechin] classes failed to induce this type of response. Among the anthocyanins, delphinidin (maximal relaxation being 89%), but not malvidin or cyanidin, showed endothelium-dependent vasorelaxation. These results show that anthocyanins and oligomeric-condensed tannins exhibited a pharmacological profile comparable to the original RWPC. These compounds may be involved in the reduction of cardiovascular mortality related to the presence of wine, fruits and vegetables in the diet.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/128.12.2324</identifier><identifier>PMID: 9868177</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutritional Sciences</publisher><subject>Animals ; Aorta, Thoracic ; Biological and medical sciences ; Blood vessels ; Blood vessels and receptors ; Diet ; Dose-Response Relationship, Drug ; Flavonoids ; Fundamental and applied biological sciences. Psychology ; Life Sciences ; Male ; Muscle, Smooth, Vascular - drug effects ; Nitric Oxide ; Nutrition ; Pharmaceutical sciences ; Phenols - administration & dosage ; Phenols - isolation & purification ; Phenols - pharmacology ; Polymers - administration & dosage ; Polymers - isolation & purification ; Polymers - pharmacology ; Polyphenols ; Rats ; Rats, Wistar ; Rodents ; Structure-Activity Relationship ; Vasodilation - drug effects ; Vertebrates: cardiovascular system ; Wine</subject><ispartof>The Journal of Nutrition, 1998-12, Vol.128 (12), p.2324-2333</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Institute of Nutrition Dec 1998</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-a799609a43e87624a08ec205b7181a8f951ca63ae5b109fd6ff8b6aaba065f3f3</citedby><cites>FETCH-LOGICAL-c486t-a799609a43e87624a08ec205b7181a8f951ca63ae5b109fd6ff8b6aaba065f3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1668525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9868177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02519330$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>ANDRIAMBELOSON, E</creatorcontrib><creatorcontrib>MAGNIER, C</creatorcontrib><creatorcontrib>HAAN-ARCHIPOFF, G</creatorcontrib><creatorcontrib>LOBSTEIN, A</creatorcontrib><creatorcontrib>ANTON, R</creatorcontrib><creatorcontrib>BERETZ, A</creatorcontrib><creatorcontrib>STOCLET, J. C</creatorcontrib><creatorcontrib>ANDRIANTSITOHAINA, R</creatorcontrib><title>Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta</title><title>The Journal of Nutrition</title><addtitle>J Nutr</addtitle><description>This study investigated the possible active principles which support the endothelial nitric oxide-dependent relaxation produced by red wine and other plant polyphenolic compounds in thoracic aorta from male Wistar rats (12-14 wk old). Relaxation experiments were recorded isometrically on vessels precontracted with norepinephrine. Ten different chromatographic fractions (3-18 mg) isolated from red wine polyphenolic compounds (RWPC) and some available defined polyphenols (10-15 mg) were tested. Fractions enriched into either anthocyanins or oligomeric condensed tannins exhibited endothelium-dependent vasorelaxant activity (maximal relaxation in the range of 59-77%) comparable to the original RWPC. However, polymeric condensed tannins elicited a weaker vasorelaxant activity than the original RWPC (maximal relaxation ranged between 20-47%, P < 0.01). Moreover, the representative of either phenolic acid derivatives (benzoic acid, vanillic acid, gallic acid), hydroxycinnamic acid (p-coumaric acid, caffeic acid) or the flavanol [(+)-epicatechin] classes failed to induce this type of response. Among the anthocyanins, delphinidin (maximal relaxation being 89%), but not malvidin or cyanidin, showed endothelium-dependent vasorelaxation. These results show that anthocyanins and oligomeric-condensed tannins exhibited a pharmacological profile comparable to the original RWPC. These compounds may be involved in the reduction of cardiovascular mortality related to the presence of wine, fruits and vegetables in the diet.</description><subject>Animals</subject><subject>Aorta, Thoracic</subject><subject>Biological and medical sciences</subject><subject>Blood vessels</subject><subject>Blood vessels and receptors</subject><subject>Diet</subject><subject>Dose-Response Relationship, Drug</subject><subject>Flavonoids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Nitric Oxide</subject><subject>Nutrition</subject><subject>Pharmaceutical sciences</subject><subject>Phenols - administration & dosage</subject><subject>Phenols - isolation & purification</subject><subject>Phenols - pharmacology</subject><subject>Polymers - administration & dosage</subject><subject>Polymers - isolation & purification</subject><subject>Polymers - pharmacology</subject><subject>Polyphenols</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Structure-Activity Relationship</subject><subject>Vasodilation - drug effects</subject><subject>Vertebrates: cardiovascular system</subject><subject>Wine</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFrFDEUxoModVu9ehMGEcHDbPOSmUxyLEVbYdGLnsObTMadJZOMSaa0_71Zdqng4RFevl--8PER8g7oFqji1wd_DUxugW0ZZ80LsoG2gVoApS_JhlLGag5CvCaXKR0opdAoeUEulBQSum5Dfn_HvEZ01TDZjPGpWoJ7WvbWBzeZyoR5CasfUmVwTbayfgh5b920zvVgl7Jan6sHTCFah4-Yp-CryVcRc5X3IaIpJhhixjfk1Ygu2bfn84r8-vrl5-19vftx9-32ZlebRopcY6eUoAobbmUnWINUWsNo23cgAeWoWjAoONq2L-nHQYyj7AVij1S0Ix_5Ffl88t2j00uc5pJJB5z0_c1OH-8oa0FxTh-gsJ9O7BLDn9WmrOcpGescehvWpIUCRkGKAn74DzyENfqSQ4PqGq462hRoe4JMDClFOz5_D1Qfq9IHr0tVZfSxqvLg_dl17Wc7POPnbor-8axjMujGiN5M6Z-rELJlLf8LAKmcgQ</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>ANDRIAMBELOSON, E</creator><creator>MAGNIER, C</creator><creator>HAAN-ARCHIPOFF, G</creator><creator>LOBSTEIN, A</creator><creator>ANTON, R</creator><creator>BERETZ, A</creator><creator>STOCLET, J. C</creator><creator>ANDRIANTSITOHAINA, R</creator><general>American Society for Nutritional Sciences</general><general>American Institute of Nutrition</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19981201</creationdate><title>Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta</title><author>ANDRIAMBELOSON, E ; MAGNIER, C ; HAAN-ARCHIPOFF, G ; LOBSTEIN, A ; ANTON, R ; BERETZ, A ; STOCLET, J. C ; ANDRIANTSITOHAINA, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-a799609a43e87624a08ec205b7181a8f951ca63ae5b109fd6ff8b6aaba065f3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Aorta, Thoracic</topic><topic>Biological and medical sciences</topic><topic>Blood vessels</topic><topic>Blood vessels and receptors</topic><topic>Diet</topic><topic>Dose-Response Relationship, Drug</topic><topic>Flavonoids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Nitric Oxide</topic><topic>Nutrition</topic><topic>Pharmaceutical sciences</topic><topic>Phenols - administration & dosage</topic><topic>Phenols - isolation & purification</topic><topic>Phenols - pharmacology</topic><topic>Polymers - administration & dosage</topic><topic>Polymers - isolation & purification</topic><topic>Polymers - pharmacology</topic><topic>Polyphenols</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Structure-Activity Relationship</topic><topic>Vasodilation - drug effects</topic><topic>Vertebrates: cardiovascular system</topic><topic>Wine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANDRIAMBELOSON, E</creatorcontrib><creatorcontrib>MAGNIER, C</creatorcontrib><creatorcontrib>HAAN-ARCHIPOFF, G</creatorcontrib><creatorcontrib>LOBSTEIN, A</creatorcontrib><creatorcontrib>ANTON, R</creatorcontrib><creatorcontrib>BERETZ, A</creatorcontrib><creatorcontrib>STOCLET, J. 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C</au><au>ANDRIANTSITOHAINA, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta</atitle><jtitle>The Journal of Nutrition</jtitle><addtitle>J Nutr</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>128</volume><issue>12</issue><spage>2324</spage><epage>2333</epage><pages>2324-2333</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>This study investigated the possible active principles which support the endothelial nitric oxide-dependent relaxation produced by red wine and other plant polyphenolic compounds in thoracic aorta from male Wistar rats (12-14 wk old). Relaxation experiments were recorded isometrically on vessels precontracted with norepinephrine. Ten different chromatographic fractions (3-18 mg) isolated from red wine polyphenolic compounds (RWPC) and some available defined polyphenols (10-15 mg) were tested. Fractions enriched into either anthocyanins or oligomeric condensed tannins exhibited endothelium-dependent vasorelaxant activity (maximal relaxation in the range of 59-77%) comparable to the original RWPC. However, polymeric condensed tannins elicited a weaker vasorelaxant activity than the original RWPC (maximal relaxation ranged between 20-47%, P < 0.01). Moreover, the representative of either phenolic acid derivatives (benzoic acid, vanillic acid, gallic acid), hydroxycinnamic acid (p-coumaric acid, caffeic acid) or the flavanol [(+)-epicatechin] classes failed to induce this type of response. Among the anthocyanins, delphinidin (maximal relaxation being 89%), but not malvidin or cyanidin, showed endothelium-dependent vasorelaxation. These results show that anthocyanins and oligomeric-condensed tannins exhibited a pharmacological profile comparable to the original RWPC. These compounds may be involved in the reduction of cardiovascular mortality related to the presence of wine, fruits and vegetables in the diet.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutritional Sciences</pub><pmid>9868177</pmid><doi>10.1093/jn/128.12.2324</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of Nutrition, 1998-12, Vol.128 (12), p.2324-2333 |
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| subjects | Animals Aorta, Thoracic Biological and medical sciences Blood vessels Blood vessels and receptors Diet Dose-Response Relationship, Drug Flavonoids Fundamental and applied biological sciences. Psychology Life Sciences Male Muscle, Smooth, Vascular - drug effects Nitric Oxide Nutrition Pharmaceutical sciences Phenols - administration & dosage Phenols - isolation & purification Phenols - pharmacology Polymers - administration & dosage Polymers - isolation & purification Polymers - pharmacology Polyphenols Rats Rats, Wistar Rodents Structure-Activity Relationship Vasodilation - drug effects Vertebrates: cardiovascular system Wine |
| title | Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta |
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