Syntheses and antitumor activity of cis-restricted combretastatins: 5-Membered heterocyclic analogues
A series of cis-restricted combretastatin analogues with 5-membered heterocycles were synthesized and their inhibitory activity against microtubule assembly and cytotoxic activity against the colon 26 adenocarcinoma cancer cell line were evaluated. Some of the heterocyclic analogues showed potent an...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1998-11, Vol.8 (22), p.3153-3158 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Ohsumi, Koji Hatanaka, Toshihiro Fujita, Koichi Nakagawa, Ryusuke Fukuda, Yumiko Nihei, Yukio Suga, Yasuyo Morinaga, Yoshihiro Akiyama, Yukio Tsuji, Takashi |
| description | A series of cis-restricted combretastatin analogues with 5-membered heterocycles were synthesized and their inhibitory activity against microtubule assembly and cytotoxic activity against the colon 26 adenocarcinoma cancer cell line were evaluated. Some of the heterocyclic analogues showed potent antitubulin activity and cytotoxicity. Compounds
16 and
35 showed marked tumor growth suppression in the colon 26 murine tumor model.
The syntheses and antitumor activity of cis-restricted AC-7739 analogues are discussed. |
| doi_str_mv | 10.1016/S0960-894X(98)00579-4 |
| format | Article |
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16 and
35 showed marked tumor growth suppression in the colon 26 murine tumor model.
The syntheses and antitumor activity of cis-restricted AC-7739 analogues are discussed.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(98)00579-4</identifier><identifier>PMID: 9873694</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antineoplastic agents ; Antineoplastic Agents, Phytogenic - chemical synthesis ; Biological and medical sciences ; Cattle ; General aspects ; Humans ; Medical sciences ; Pharmacology. Drug treatments ; Stilbenes - chemical synthesis ; Stilbenes - pharmacology ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (22), p.3153-3158</ispartof><rights>1998</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-e6120ff5ba2075f743591acad225dee58208d4a58e78e43886f658e05357608c3</citedby><cites>FETCH-LOGICAL-c389t-e6120ff5ba2075f743591acad225dee58208d4a58e78e43886f658e05357608c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0960-894X(98)00579-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1630978$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9873694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohsumi, Koji</creatorcontrib><creatorcontrib>Hatanaka, Toshihiro</creatorcontrib><creatorcontrib>Fujita, Koichi</creatorcontrib><creatorcontrib>Nakagawa, Ryusuke</creatorcontrib><creatorcontrib>Fukuda, Yumiko</creatorcontrib><creatorcontrib>Nihei, Yukio</creatorcontrib><creatorcontrib>Suga, Yasuyo</creatorcontrib><creatorcontrib>Morinaga, Yoshihiro</creatorcontrib><creatorcontrib>Akiyama, Yukio</creatorcontrib><creatorcontrib>Tsuji, Takashi</creatorcontrib><title>Syntheses and antitumor activity of cis-restricted combretastatins: 5-Membered heterocyclic analogues</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A series of cis-restricted combretastatin analogues with 5-membered heterocycles were synthesized and their inhibitory activity against microtubule assembly and cytotoxic activity against the colon 26 adenocarcinoma cancer cell line were evaluated. Some of the heterocyclic analogues showed potent antitubulin activity and cytotoxicity. Compounds
16 and
35 showed marked tumor growth suppression in the colon 26 murine tumor model.
The syntheses and antitumor activity of cis-restricted AC-7739 analogues are discussed.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents, Phytogenic - chemical synthesis</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Some of the heterocyclic analogues showed potent antitubulin activity and cytotoxicity. Compounds
16 and
35 showed marked tumor growth suppression in the colon 26 murine tumor model.
The syntheses and antitumor activity of cis-restricted AC-7739 analogues are discussed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9873694</pmid><doi>10.1016/S0960-894X(98)00579-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (22), p.3153-3158 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Biological and medical sciences Cattle General aspects Humans Medical sciences Pharmacology. Drug treatments Stilbenes - chemical synthesis Stilbenes - pharmacology Structure-Activity Relationship |
| title | Syntheses and antitumor activity of cis-restricted combretastatins: 5-Membered heterocyclic analogues |
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