Structural determinants of substrates and inhibitors : Probing glutamate transporters with 2,4-methanopyrrolidine-2,4-dicarboxylate
Using an intramolecular [2 + 2] photocyclization, 2,4-methanopyrrolidine-2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate subs...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1998-11, Vol.8 (21), p.3101-3106 |
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| container_end_page | 3106 |
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| container_issue | 21 |
| container_start_page | 3101 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 8 |
| creator | ESSLINGER, C. S KOCH, H. P KAVANAUGH, M. P PHILIPS, D. P CHAMBERLIN, A. R THOMPSON, C. M BRIDGES, R. J |
| description | Using an intramolecular [2 + 2] photocyclization, 2,4-methanopyrrolidine-2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter. |
| doi_str_mv | 10.1016/S0960-894X(98)00560-5 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (21), p.3101-3106 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69118451 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Transport System X-AG Animals ATP-Binding Cassette Transporters - antagonists & inhibitors Biological and medical sciences Dicarboxylic Acids - chemical synthesis Glutamatergic system (aspartate and other excitatory aminoacids) Glutamic Acid - analogs & derivatives Male Medical sciences Molecular Conformation Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Pyrrolidines - chemical synthesis Rats Rats, Sprague-Dawley |
| title | Structural determinants of substrates and inhibitors : Probing glutamate transporters with 2,4-methanopyrrolidine-2,4-dicarboxylate |
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