Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs

An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7- O-TES-10-deacetylbaccatin III and appropriate alkenes. In addition the cytotoxic activity of 10-alkylated docetaxel analogs was evaluated. Among these analo...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-03, Vol.8 (5), p.427-432
Hauptverfasser:	Nakayama, Kiyoshi, Terasawa, Hirofumi, Mitsui, Ikuo, Ohsuki, Satoru, Uoto, Kouichi, Iimura, Shin, Soga, Tsunehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Docetaxel General aspects Medical sciences Models, Molecular Paclitaxel - analogs & derivatives Paclitaxel - chemical synthesis Paclitaxel - chemistry Paclitaxel - pharmacology Pharmacology. Drug treatments Taxoids Tumor Cells, Cultured
Online-Zugang:	Volltext
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